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lunes, 24 de febrero de 2014
Postdoctoral position on Telomeres
A Postdoctoral position is available in the laboratory of Miguel Godinho
Ferreira to study DNA damage responses at telomeres in fission yeast. The
laboratory is located at Instituto Gulbenkian de Ciência near Lisbon, Portugal.
We are looking for a highly motivated scientist with a strong background
in molecular biology and DNA damage responses willing to work in
multidisciplinary environment that encompasses molecules, organism and
disease. We are funded by Howard Hughes Medical Institute (USA) and the
Foundation for Science and Technology (Portugal).
Based on previous work from our group (Carneiro et al. Nature 2010), we
are unravelling the mechanisms preventing the recognition of telomeres as DNA
double-strand breaks. We propose that epigenetic
environment at telomeres represents the hallmark of
chromosome ends that distinguishes them from
deleterious DNA lesions. To gain insights into the
existence of such “chromatin privileged regions”, we
are studying histone modifications both on nuclease
induced DSBs and telomeres.
The Instituto Gulbenkian de Ciência (http://www.igc.pt) is the Portuguese
flagship of biomedical research. English is the main language in the campus (all
seminars and communications are in English) and we have a significant foreign
scientific community (ca. 30% from 34 countries). The Institute is privately
supported by the Gulbenkian Foundation to carry biomedical
research and education. The IGC offers excellent facilities and
services to foreign and Portuguese research groups, in
particular to young post-doctoral fellows. Attesting this,
TheScientist/F1000 awarded us with the title Best Place to Work
for postdocs in 2010 and 2011.
Candidates are encouraged to send a cover letter, Curriculum vitae and
two reference letters to Miguel Godinho Ferreira by email
(mgferreira@igc.gulbenkian.pt) under the subject: “Postdoctoral position” by 28th
February.
For more information, please visit our web site:
http://sites.igc.gulbenkian.pt/telomere/
25 contratos para Jóvenes Investigadores
Ikerbasque ha lanzado una nueva convocatoria internacional para fortalecer
la investigación científica en Euskadi en las que ofrecen:
25 contratos para Jóvenes Investigadores: Ikerbasque Research Fellows
o Contratos de 5 años de duración
o Dirigido a personas doctoradas entre enero de 2004 y diciembre de 2011
o Se requiere carta de aceptación del centro de acogida
o Fecha límite solicitud: 31 de marzo de 2014 a las 13:00
Para más información sobre esta convocatoria: www.ikerbasque.net
lunes, 17 de febrero de 2014
OFERTA TESIS DOCTORAL
OFERTA TESIS DOCTORAL EN EL CENTRO DE INVESTIGACION DEL CANCER DE SALAMANCA
Grupo del Centro de Investigación del Cáncer de Salamanca ofrece una
posición para la realización de una Tesis Doctoral a licenciados o
estudiantes de los últimos años de Biología, Medicina o Farmacia que
tengan buen expediente académico y estén interesados en los campos de la
autofagia, la muerte celular programada y el cáncer.
El proyecto que se propone se basa en la caracterización funcional de
nuevos genes participantes en la regulación de la autofagia celular y la
muerte celular programada en mamíferos.
Interesados enviar CV (indicando nota media del expediente) a:
Dr. Felipe X. Pimentel-Muiños, Lab18
Centro de Investigación del Cáncer
Salamanca
Teléfono: 923-294818
e-mail: fxp@usal.es
http://www.cicancer.org/vergrupo.php?IdGrupo=1005
viernes, 14 de febrero de 2014
Lecturer in Biosciences (x3)- School of Bioscience; University of Kent, Canterbury UK
Closing date: 03 Mar 2014
The Role
We are seeking applications from active research scientists in the area of Molecular Biosciences. We will consider applications from those who are looking for their first academic post as well as from individuals who already have hold a permanent or fixed-term position in a UK or overseas academic or research institution. We also wish to encourage applications from those that hold a major research fellowship (e.g. MRC Career Development Fellowship, Leverhulme Trust Early Career, Wellcome Trust Research Career Development Fellowship, Long-Term EMBO Fellowship etc).
The Person
The appointee will deliver both research and teaching and be based within the School of Biosciences. Furthermore, the appointee will be expected to obtain research funding in their area of expertise to fully support the position, publish in high impact peer-reviewed journals and develop cross-disciplinary projects with colleagues across the Sciences faculty.
The School
The School of Biosciences is part of the Faculty of Sciences and teaches undergraduate degree programmes in Biochemistry, Biology and Biomedical Sciences, complimented with a portfolio of postgraduate programmes both taught and research focussed. The School also strongly profits from its close links with the East Kent Hospitals NHS Trust Pathology Service.
The School of Biosciences opened in 1970 and was founded on the principle that considerable benefits are to be gained through exploiting multidisciplinary approaches to biological research and enterprise activities. The School, which is consistently ranked in the top 30 biological science Schools in the UK, houses a dynamic research community made up of 15 research groups each with a strong national (and in many cases international) reputation for their research. This environment also provides an excellent setting for our postgraduate training programmes at the PhD and MSc level.
Research in the School is focused on molecular and cellular biosciences and spans both basic research and clinical applications. There are three principal areas of research activity:
Protein science
Molecular Biology
Biomolecular Medicine
Website: www.kent.ac.uk/bio
Further Information
Start date for applications: 21 Jan 2014
Closing date for applications: 03 Mar 2014
Interviews are to be held: 31 Mar 2014
Please apply at http://www11.i-grasp.com/fe/tpl_kent01.asp?newms=jj&id=38199&aid=14243
3-year Marie Curie fellowship at the University of Braunschweig, Germany
We are seeking a highly motivated student for a PhD thesis research project addressing directed
growth and cell fusion in fungi. We are using the filamentous fungus Neurospora crassa as a model
organism to investigate molecular mechanisms mediating cell-cell communication resulting in cellmerger
(for more information please visit: https://www.tu-braunschweig.de/ifg/ag/fleissner). The aim of
this project is to describe the relationship between activity and subcellular localization of signaling
proteins and to identify the underlying signaling network mediating tropic growth and plasma membrane
fusion. A combination of genetic, molecular, biochemical methods and state-of-the-art imaging
techniques, including live-cell imaging, will be used.
The project is part of a Marie Curie ITN consortium of 12 European academic and industrial laboratories
working at the forefront of fungal research on a project entitled “Sensing and integration of signals
governing cell polarity and tropism in fungi” (FUNGIBRAIN) and will provide extensive training
opportunities. For further information please visit:
http://www.inflammation-repair.manchester.ac.uk/FungiBrain
We are seeking candidates with a strong background in molecular genetics, cell biology and
fluorescence microscopy. Ideally, candidates have a background in fungal or yeast biology.
There are strict eligibility requirements which apply to all Marie Curie Early Stage Researchers (ESRs).
At the time of appointment, applicants should not hold a PhD or have more than 4 years research
experience (FTE) after Masters graduation (applicants may have spent longer in industrial/junior
management roles) and should not have resided in the project host country for more than 12 months in
the last 3 years immediately before appointment.
To apply, please send a motivation letter, a curriculum vitae and the names and contact
information of two referees to:
André Fleißner (a.fleissner@tu-bs.de)
viernes, 7 de febrero de 2014
Oferta de empleo para Técnico de laboratorio en CNIC
Técnico con Experiencia para trabajar en el grupo de
“Metaloproteinasas de Matriz en Angiogénesis e
Inflamación” (TEC-MMAI2014)
La persona seleccionada tendrá como función principal la realización directa de los
ensayos experimentales que sean requeridos para alcanzar los objetivos científicos de
los diferentes proyectos del grupo de investigación. Además, será parte de su trabajo la
organización diaria del laboratorio y la gestión de pedidos
Requerimos
Titulación mínima de Técnico FPII, aunque titulados superiores pueden
inscribirse.
Imprescindible demostrar una experiencia mínima de 3-4 años en entornos de
investigación similares al CNIC.
Conocimiento alto de inglés tanto hablado como escrito. Se requiere un dominio
del inglés suficiente para poder trabajar en un entorno internacional cuyo idioma
de comunicación es el inglés
Capacidad para la ejecución efectiva de tareas experimentales.
Experiencia demostrable en las siguientes técnicas:
o Trabajo con animales (imprescindible homologación B)
o Histología
o Técnicas usuales de biología molecular (PCR, Western Blot, etc)
o Cultivos celulares
Persona con capacidad organizativa demostrable y capacidad para asumir
decisiones en el ámbito de su responsabilidad.
Ofrecemos
Salario competitivo, a convenir según cualificación
La oportunidad de integrarse en un centro de investigación en plena expansión,
con excelentes expectativas de crecimiento.
Si estás interesado, manda tu CV a aquesada@cnic.es indicando en el campo
asunto el código TEC-MMAI2014 o inscríbete en la oferta de empleo publicada en
la sección “Trabajar en CNIC” de nuestra web
(http://www.cnic.es/es/empleo/ofertas.php)
9-months position at MRC-Laboratory of Molecular Biology in Cambridge
A 9-months position is available in the lab of Dr Katja Röper at the
MRC-Laboratory of Molecular Biology in Cambridge, ideally starting at the
beginning of April 2014.
>
> We study the cell biological basis of tissue morphogenesis, and in particular how
cell shape is controlled by the cytoskeleton and upstream regulators.
>
> The ideal candidate would have some experience with Drosophila and confocal
imaging. The project will involve fly husbandry, confocal time-lapse imaging and
image analysis. In particular, we want to analyse cell shape changes in 4D in
comparison to localisation of cytoskeletal components during the early
invagination of the salivary glands in the fly embryo.
>
> Candidates could be recent graduates with relevant undergraduate lab experience,
or someone who recently obtained a PhD and has to bridge time between
appointments.
>
> If you are interested, please contact Dr Katja Röper by email at
>
> kroeper@mrc-lmb.cam.ac.uk.
>
> For more information on our research visit our lab website at
>
> http://www2.mrc-lmb.cam.ac.uk/research/cellbiology/katja-roeper/
Research Associate offer in UCL
Research Associate X 2, - Ref:1399630
UCL Department / Division
MRC Laboratory for Molecular Cell Biology
Grade
7
Hours
Full Time
Salary
(inclusive of London allowance)
£32,699 - £39,523 inclusive per annum
Duties and Responsibilities
The Mao lab studies the mechanics of tissue growth and regeneration, combining genetics, in vivo live imaging, automated image analysis, experimental biophysics and computational modelling. Current projects in the lab include interdisciplinary approaches to study how mechanical forces affect tissue growth, tissue architectural changes, cell shape changes during mitosis and tissue regeneration in the Drosophila wing disc.
We are looking for an experienced developmental or cell biologist to study the mechanics of in vivo 3D tissue growth, using initially the Drosophila wing as a model system.
Available from March 2014, one post is offered for a period of three years in the first instance and the other for one year in the first instance.
Key Requirements
Candidates should possess / or shortly be awarded a PhD degree in biology, biophysics, or a related biological sciences discipline. A strong background in advanced live imaging, cell / tissue mechanics, quantitative image analysis, molecular and cell biology are required. Experience with Drosophila genetics, tissue mechanical measurements and tissue manipulation techniques are advantageous.
Further Details
A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the Apply Now button below.
If you have any queries regarding the application process, please contact Ione Karney i.karney@ucl.ac.uk
Highly committed candidates are encouraged to contact Yanlan Mao by email at y.mao@ucl.ac.uk.
UCL Taking Action for Equality
Closing Date
20 Feb 2014
Latest time for the submission of applications
5.00pm
This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff.
Please use these links to find out more about the UCL Terms and Conditions related to this job, employee benefits that we offer and further information about UCL.
Job description and person specification
Contrato postdoctoral dentro del programa del MINECO
Se ofrece la posibilidad de un contrato postdoctoral dentro del programa del MINECO
(Subprograma Estatal de Formación, BOE nº313, 31 de diciembre de 2013) en una de las líneas
de investigación activas en el Servicio de Micología, del CNM-ISCIII
Proponemos la incorporación a un proyecto de investigación que contempla varias vertientes
relacionadas. Por un lado nuestro grupo trabaja en el desarrollo y estandarización de métodos
cromatrográficos relacionados con la monitorización de tratamientos, estudios
farmacocinéticos en modelos animales, etc…y por otro, estamos desarrollando metodologías
destinadas a evaluar variantes genéticas humanas y su relación con el metabolismo de
antifúngicos.
Buscamos un candidato que cumpla los siguientes requisitos:
• Haber finalizado su tesis doctoral con posterioridad al 1 de septiembre de 2009.
• Haber realizado la tesis doctoral en un OPI distinto al ISCIII
• Tener gran motivación por la investigación
• Acreditar publicaciones de nivel científico relacionadas con el campo del proyecto a
desarrollar
• Disponer de un buen nivel de inglés
Es además muy valorable:
• Experiencia demostrada en manejo de equipos HPLC
• Experiencia en el manejo de software PK/PD
• Experiencia en genética humana
Más información sobre nuestro grupo en la siguiente dirección electrónica:
http://www.isciii.es/ISCIII/es/contenidos/fd-el-instituto/fd-organizacion/fd-estructura-directiva/fd-subdirecciongeneral-
servicios-aplicados-formacion-investigacion/fd-centros-unidades/fd-centro-nacional-
Microbiologia/Publicientificas_Bacteriologia_Micologia_Parasitologia.pdf
Los interesados han de enviar su CV a Alicia Gómez- López (aliciagl@isciii.es) antes del 11 de
febrero de 2014. El plazo de presentación de solicitudes al MINECO es del 12 al 24 de febrero
de 2014.
Postdoctoral Researcher
Comparative Cell Biology and Pharmacology of Disease
Department of Comparative Biomedical Sciences
Royal Veterinary College, Camden, London
Salary: c. £31.1k pa inclusive
Contract length: 2 years
Closing Date: 4 March 2014
Job Ref: CBS-0008-14
Interviews: likely to be held the week beginning 24 March 2014
Topic: Metabolic defects in Neurodegeneration
Job summary:
Defects in mitochondria and lysosomes, which may result in a lack of specific
metabolites, have been implicated in a variety of neurodegenerative diseases, including
Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL), a paediatric progressive
neurodegenerative disease that is the focus of this research.
Aim
The post is full time and the successful applicant will be responsible for running the
experimental program outlined in the awarded grant. We will use the zebrafish model to
determine whether defects in autophagy or mitochondria contribute to LINCL pathology
and determine if nutritional supplements or upregulation of mitochondrial ATPsynthase
Inhibitory Factor 1 (IF1) function ameliorates the neurodegenerative phenotype of the
zebrafish model of LINCL, therefore indicating if this approach has potential for treating
affected children. The team leaders Drs. Claire Russell and Michelangelo Campanella
will provide training in the key techniques.
Your profile
Applicants must have a PhD in a biological science, experience using zebrafish or
performing mitochondrial and autophagy assays, ability to troubleshoot and optimise
experiments, and effective teamwork and communication skills, with a high degree of
motivation.
Informal enquiries to Dr Claire Russell crussell@rvc.ac.uk or Dr Michelangelo
Campanella mcampanella@rvc.ac.uk
The tentative start date for this role is June 2014.
We offer a generous reward package including a pension scheme.
For further information and to apply on-line please visit our website:
www.rvc.ac.uk
miércoles, 5 de febrero de 2014
Postdoctoral positions NYC WCMC
McGraw lab - Biochemistry
Postdoctoral position
Project: Studies of insulin action in adipocytes. The work entails using
molecular cell biological methods and quantitative fluorescence microscopy
to dissect the mechanism by which insulin regulates the trafficking of the
glut4 glucose transporter to the plasma membrane. This process is key for
the regulation of whole body glucose homeostasis. The process is
disrupted in insulin resistance and type 2 diabetes. The position is
available immediately. Contact: temcgraw@med.cornell.edu
McGraw lab - Biochemistry
Postdoctoral position
Project: Studies of the GIP incretin hormone system. GIP is a hormone
produced by K-cells of the gastrointestinal track in response to food.
GIP has a critical role in setting the tone of insulin response. The
project entails using molecular cell biological methods and quantitative
fluorescence microscopy to study the GIP/GIP receptor in cultured
adipocytes. The position is available immediately. Contact:
temcgraw@med.cornell.edu
McGraw and Altorki Lab - Biochemistry and CT Surgery
Postdoctoral position. Project: Studies of the roles of fibroblasts in
lung cancer. The project entails using mass spectrometry and RNAseq
methods to establish a pro-tumorigenic profile of tumor-promoting
fibroblasts. The pro-tumorigenic profile will be validated and tested in
cell-based and animal studies. The objective of this work is to identify
fibroblasts activities that promote tumorigenic, with the long-term
objective of developing methods to therapeutically target these
activities. The position is available immediately. Contact:
temcgraw@med.cornell.edu
Postdoc position in Marburg
The Institute of Pharmacology at the Biochemical-Pharmacological Center
of the Uni- versity of Marburg (group of Prof. Dr. Thomas Worzfeld;
www.bpc-marburg.de) invites applications for a
Postdoc position in the field of Cancer Research and Pharmacology
We are studying the biological roles of the semaphorin-plexin signaling
system in can- cer and during epithelial organ repair (PNAS 2014; J.
Clin. Invest 2012).
We apply molecular and cellular biology techniques, biochemistry,
advanced imaging, generation of constitutive and conditional mouse
mutants, BAC transgenics in mice, and histology.
We are seeking for an enthusiastic, highly motivated and creative
scientist with a back- ground in molecular and cellular biology.
Knowledge of mammalian physiology and ex- perience with mice and/or with
advanced imaging techniques would be advantageous.
We offer a dynamic working environment at the
Biochemical-Pharmacological Center of the University of Marburg, one of
the most beautiful old university towns in Europe, and a stimulating
scientific surrounding in a young, international and motivated team. The
position is immediately available.
Applicants should send their statement of interest, a full CV and the
name and address of at least two references to
thomas.worzfeld@staff.uni-marburg.de.
Oferta posición postdoctoral
REQUISITOS:
- Doctor en biología, farmacia, medicina, bioquímica, biotecnología, y/o otras relacionadas con el campo de la salud.
- Experiencia post-doctoral. Dirección de tesis y coordinación de Becarios/Proyectos.
- Curriculum competitivo con publicaciones preferentemente como primer, último autor o autor de correspondencia. El candidato ha de tener un mínimo de 4 publicaciones como primer, último autor o autor de correspondencia en revistas de alto impacto (1er cuartil) en los últimos 10 años.
- Se requiere experiencia previa en obtención de financiación competitiva en el ámbito de la investigación fundamental o traslacional, en convocatorias de proyectos del Plan Nacional de I+D+i u otras convocatorias competitivas nacionales e internacionales.
- Buen dominio de la lengua inglesa hablada y escrita.
- Se requieren capacidades para ser responsable de un grupo de investigación o de una línea de investigación en colaboración con la clínica. Conocimientos y experiencia en ciclo celular y/o angiogénesis
Técnicas básicas necesarias
-PCR/real time/retrotranscriptasa
- Electroforesis y secuenciación
-Western Blott
-ELISA
-Inmunohistoquímica
-Microscopía (Óptica, Fluorescente y Confocal)
-Citometría de Flujo
-Cultivo celular y/o Bacteriano
ITEMS EXTRA VALORADOS:
- Experiencia en investigación sobre tejido epitelial-mucosa. En especial estudios de histología y anatomía patológica
- Experiencia en enfermedades inmunes, inflamatorias o infecciosas bacterianas ( I3)
- Se tendrán en cuenta otras aportaciones de la investigación, incluyendo la transferencia de conocimiento: los libros o capítulos de libros científicos y técnicos. Así como las indicativas de la capacidad de gestión de I+D+i y de transferencia de tecnología: proyectos concedidos, patentes concedidas, patentes licenciadas, participación en contratos de colaboración, etc.
Técnicas de laboratorio deseables
-Cultivo de tejido o de células obtenidas de tejido
-Clonación/transfección ADN
-Northern y Southern Blott
-DNA arrays
-Inmunoprecipitación (IP) y coIP
-2D y 3D electroforesis
CARACTERÍSTICAS DEL PUESTO: - Dirección, desarrollo y coordinación de proyectos con carácter traslacional de investigación básica en estrecha colaboración con la clínica sobre enfermedad inflamatoria intestinal e infección por Helicobacter pylori
- Contrato con altas posibilidades de permanencia
- Ambiente académico activo y estimulante de elevada producción científica
Apply for a Postdoc Position at the CDC
http://emessaging.vertexcommunication.com/p/vJYdorr8nN
Check Out ASM Professional Development Opportunities for Your
Grad Students and Postdocs
Postdoctoral Research Scientist: Stromal Cell Immunology
Postdoctoral Research Scientist: Stromal Cell Immunology (Ref: OTL-2014-01).
Orbsen Therapeutics is seeking a talented and experienced Immunologist
to study role of stromal cells in controlling innate and adaptive
responses to inflammatory disease.
A PhD degree in Immunology and experience in developing transgenic
models of disease are essential. Experience in flow cytometry, cell
culture, lymphocyte function assays, QPCR, protein assays and histology
are also highly desirable.
Applications are invited from suitably qualified candidates for a full
time EU FP7-funded, 3-year fixed-term position at Orbsen Therapeutics
Ltd. in Galway, Ireland.
Salary: EU €45,000-50,000 annually depending on skills and experience.
The position is available to start February 17th 2014.
Orbsen Therapeutics is Ireland's leading cell therapy company. We have
identified, developed and patented a novel marker that enables
best-in-class purification of therapeutic stromal cells from a variety
of sources including bone marrow and umbilical cord. With 23 clinical,
academic and commercial partners across Europe and the US, Orbsen is
developing this cell therapy for the microvascular complications of
diabetes (MCD), primary sclerosing cholangitis (PSC) and acute
respiratory distress syndrome (ARDS).
To apply please email: steve.elliman@orbsentherapeutics.com
Please attach CV, Letter of Interest and 3 references
Closing date: 24th February 2014
For further information, please contact (no agencies please):
Steve Elliman. Head of R&D, Orbsen Therapeutics Ltd.
Email: steve.elliman@orbsentherapeutics.com
Position available for application to the Spanish MINECO Postdoctoral Program
Eligibility criteria:
•PhD defended between september 2009 and june 2014.
•Candidates cannot be recipients of Ramón y Cajal or Juan de la Cierva fellowships from previous years, and cannot apply to the Ramón y Cajal Program this year.
•Candidates can only apply for 1 research Institution.
•Demonstrable experience in cellular and molecular biology and epigenetics is required. Experience on iPS cells, metabolism, massive sequencing, mice hematopoietic transplantation or mesenchymal stem cells is a plus.
•A robust CV with 2-3 publications as first author in journals of impact factor >6 are required.
•High scientific motivation, proactive attitude, communication skills and troubleshooting ability.
The project will be performed at the Medicine School of the University of Barcelona / Josep Carreras Leukemia Research Laboratory (Pablo Menendez Lab. http://www.carrerasresearch.org/). The project will use different approaches (cell and molecular biology, genetics and epigenetics, animal models, cell reprogramming, drug testing) to gain insights into the developmental and molecular mechanisms underlying the pathogenesis of pediatric leukemias.
Selected publications of the group:
Rubio et al. Stem Cells 2014 Bueno et al. Cell Res 2012 Ramos-Mejía et al. Cell Res 2010
Montes et al. Leukemia 2014 Real P et al. Mol Ther 2012 Ramos-Mejía et al. Mol Ther 2010
Meyer et al. Leukemia 2013 Rodríguez et al. Cell Res 2012 Gutierrez-Aranda et al Stem Cells 2010
Bueno et al. Blood 2013 Sanchez et al. Stem Cells 2011 Rubio et al. Cancer Res 2010
Real et al. Blood 2013 Rodríguez et al. Stem Cells 2011 Menendez et al J Exp Med 2009
Rodríguez et al. Stem Cells 2013 Montes et al. Blood 2011 Bueno et al. Carcinogenesis 2009
Rubio et al. Oncogene 2013 Bueno et al. Leukemia 2011 Montes et al. Cell Res 2009
Chilón et al. Leukemia 2012 Barroso-delJesus et al. FASEB J 2011 Barroso-delJesus et al. Mol Cell Biol 2008
Ramos-Mejía et al. Trends Mol Med 2012 García-Pérez et al. Nature 2010 Bueno et al. Leukemia 2008
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