lunes, 24 de febrero de 2014

Postdoctoral position on Telomeres

A Postdoctoral position is available in the laboratory of Miguel Godinho Ferreira to study DNA damage responses at telomeres in fission yeast. The laboratory is located at Instituto Gulbenkian de Ciência near Lisbon, Portugal. We are looking for a highly motivated scientist with a strong background in molecular biology and DNA damage responses willing to work in multidisciplinary environment that encompasses molecules, organism and disease. We are funded by Howard Hughes Medical Institute (USA) and the Foundation for Science and Technology (Portugal). Based on previous work from our group (Carneiro et al. Nature 2010), we are unravelling the mechanisms preventing the recognition of telomeres as DNA double-strand breaks. We propose that epigenetic environment at telomeres represents the hallmark of chromosome ends that distinguishes them from deleterious DNA lesions. To gain insights into the existence of such “chromatin privileged regions”, we are studying histone modifications both on nuclease induced DSBs and telomeres. The Instituto Gulbenkian de Ciência (http://www.igc.pt) is the Portuguese flagship of biomedical research. English is the main language in the campus (all seminars and communications are in English) and we have a significant foreign scientific community (ca. 30% from 34 countries). The Institute is privately supported by the Gulbenkian Foundation to carry biomedical research and education. The IGC offers excellent facilities and services to foreign and Portuguese research groups, in particular to young post-doctoral fellows. Attesting this, TheScientist/F1000 awarded us with the title Best Place to Work for postdocs in 2010 and 2011. Candidates are encouraged to send a cover letter, Curriculum vitae and two reference letters to Miguel Godinho Ferreira by email (mgferreira@igc.gulbenkian.pt) under the subject: “Postdoctoral position” by 28th February. For more information, please visit our web site: http://sites.igc.gulbenkian.pt/telomere/

25 contratos para Jóvenes Investigadores

Ikerbasque ha lanzado una nueva convocatoria internacional para fortalecer la investigación científica en Euskadi en las que ofrecen: 25 contratos para Jóvenes Investigadores: Ikerbasque Research Fellows o Contratos de 5 años de duración o Dirigido a personas doctoradas entre enero de 2004 y diciembre de 2011 o Se requiere carta de aceptación del centro de acogida o Fecha límite solicitud: 31 de marzo de 2014 a las 13:00 Para más información sobre esta convocatoria: www.ikerbasque.net

lunes, 17 de febrero de 2014

OFERTA TESIS DOCTORAL

OFERTA TESIS DOCTORAL EN EL CENTRO DE INVESTIGACION DEL CANCER DE SALAMANCA Grupo del Centro de Investigación del Cáncer de Salamanca ofrece una posición para la realización de una Tesis Doctoral a licenciados o estudiantes de los últimos años de Biología, Medicina o Farmacia que tengan buen expediente académico y estén interesados en los campos de la autofagia, la muerte celular programada y el cáncer. El proyecto que se propone se basa en la caracterización funcional de nuevos genes participantes en la regulación de la autofagia celular y la muerte celular programada en mamíferos. Interesados enviar CV (indicando nota media del expediente) a: Dr. Felipe X. Pimentel-Muiños, Lab18 Centro de Investigación del Cáncer Salamanca Teléfono: 923-294818 e-mail: fxp@usal.es http://www.cicancer.org/vergrupo.php?IdGrupo=1005

viernes, 14 de febrero de 2014

Lecturer in Biosciences (x3)- School of Bioscience; University of Kent, Canterbury UK

Closing date: 03 Mar 2014 The Role We are seeking applications from active research scientists in the area of Molecular Biosciences. We will consider applications from those who are looking for their first academic post as well as from individuals who already have hold a permanent or fixed-term position in a UK or overseas academic or research institution. We also wish to encourage applications from those that hold a major research fellowship (e.g. MRC Career Development Fellowship, Leverhulme Trust Early Career, Wellcome Trust Research Career Development Fellowship, Long-Term EMBO Fellowship etc). The Person The appointee will deliver both research and teaching and be based within the School of Biosciences. Furthermore, the appointee will be expected to obtain research funding in their area of expertise to fully support the position, publish in high impact peer-reviewed journals and develop cross-disciplinary projects with colleagues across the Sciences faculty. The School The School of Biosciences is part of the Faculty of Sciences and teaches undergraduate degree programmes in Biochemistry, Biology and Biomedical Sciences, complimented with a portfolio of postgraduate programmes both taught and research focussed. The School also strongly profits from its close links with the East Kent Hospitals NHS Trust Pathology Service. The School of Biosciences opened in 1970 and was founded on the principle that considerable benefits are to be gained through exploiting multidisciplinary approaches to biological research and enterprise activities. The School, which is consistently ranked in the top 30 biological science Schools in the UK, houses a dynamic research community made up of 15 research groups each with a strong national (and in many cases international) reputation for their research. This environment also provides an excellent setting for our postgraduate training programmes at the PhD and MSc level. Research in the School is focused on molecular and cellular biosciences and spans both basic research and clinical applications. There are three principal areas of research activity: Protein science Molecular Biology Biomolecular Medicine Website: www.kent.ac.uk/bio Further Information Start date for applications: 21 Jan 2014 Closing date for applications: 03 Mar 2014 Interviews are to be held: 31 Mar 2014 Please apply at http://www11.i-grasp.com/fe/tpl_kent01.asp?newms=jj&id=38199&aid=14243

3-year Marie Curie fellowship at the University of Braunschweig, Germany

We are seeking a highly motivated student for a PhD thesis research project addressing directed growth and cell fusion in fungi. We are using the filamentous fungus Neurospora crassa as a model organism to investigate molecular mechanisms mediating cell-cell communication resulting in cellmerger (for more information please visit: https://www.tu-braunschweig.de/ifg/ag/fleissner). The aim of this project is to describe the relationship between activity and subcellular localization of signaling proteins and to identify the underlying signaling network mediating tropic growth and plasma membrane fusion. A combination of genetic, molecular, biochemical methods and state-of-the-art imaging techniques, including live-cell imaging, will be used. The project is part of a Marie Curie ITN consortium of 12 European academic and industrial laboratories working at the forefront of fungal research on a project entitled “Sensing and integration of signals governing cell polarity and tropism in fungi” (FUNGIBRAIN) and will provide extensive training opportunities. For further information please visit: http://www.inflammation-repair.manchester.ac.uk/FungiBrain We are seeking candidates with a strong background in molecular genetics, cell biology and fluorescence microscopy. Ideally, candidates have a background in fungal or yeast biology. There are strict eligibility requirements which apply to all Marie Curie Early Stage Researchers (ESRs). At the time of appointment, applicants should not hold a PhD or have more than 4 years research experience (FTE) after Masters graduation (applicants may have spent longer in industrial/junior management roles) and should not have resided in the project host country for more than 12 months in the last 3 years immediately before appointment. To apply, please send a motivation letter, a curriculum vitae and the names and contact information of two referees to: André Fleißner (a.fleissner@tu-bs.de)

viernes, 7 de febrero de 2014

Oferta de empleo para Técnico de laboratorio en CNIC

Técnico con Experiencia para trabajar en el grupo de “Metaloproteinasas de Matriz en Angiogénesis e Inflamación” (TEC-MMAI2014) La persona seleccionada tendrá como función principal la realización directa de los ensayos experimentales que sean requeridos para alcanzar los objetivos científicos de los diferentes proyectos del grupo de investigación. Además, será parte de su trabajo la organización diaria del laboratorio y la gestión de pedidos Requerimos  Titulación mínima de Técnico FPII, aunque titulados superiores pueden inscribirse.  Imprescindible demostrar una experiencia mínima de 3-4 años en entornos de investigación similares al CNIC.  Conocimiento alto de inglés tanto hablado como escrito. Se requiere un dominio del inglés suficiente para poder trabajar en un entorno internacional cuyo idioma de comunicación es el inglés  Capacidad para la ejecución efectiva de tareas experimentales.  Experiencia demostrable en las siguientes técnicas: o Trabajo con animales (imprescindible homologación B) o Histología o Técnicas usuales de biología molecular (PCR, Western Blot, etc) o Cultivos celulares  Persona con capacidad organizativa demostrable y capacidad para asumir decisiones en el ámbito de su responsabilidad. Ofrecemos  Salario competitivo, a convenir según cualificación  La oportunidad de integrarse en un centro de investigación en plena expansión, con excelentes expectativas de crecimiento. Si estás interesado, manda tu CV a aquesada@cnic.es indicando en el campo asunto el código TEC-MMAI2014 o inscríbete en la oferta de empleo publicada en la sección “Trabajar en CNIC” de nuestra web (http://www.cnic.es/es/empleo/ofertas.php)

9-months position at MRC-Laboratory of Molecular Biology in Cambridge

A 9-months position is available in the lab of Dr Katja Röper at the MRC-Laboratory of Molecular Biology in Cambridge, ideally starting at the beginning of April 2014. > > We study the cell biological basis of tissue morphogenesis, and in particular how cell shape is controlled by the cytoskeleton and upstream regulators. > > The ideal candidate would have some experience with Drosophila and confocal imaging. The project will involve fly husbandry, confocal time-lapse imaging and image analysis. In particular, we want to analyse cell shape changes in 4D in comparison to localisation of cytoskeletal components during the early invagination of the salivary glands in the fly embryo. > > Candidates could be recent graduates with relevant undergraduate lab experience, or someone who recently obtained a PhD and has to bridge time between appointments. > > If you are interested, please contact Dr Katja Röper by email at > > kroeper@mrc-lmb.cam.ac.uk. > > For more information on our research visit our lab website at > > http://www2.mrc-lmb.cam.ac.uk/research/cellbiology/katja-roeper/

Research Associate offer in UCL

Research Associate X 2, - Ref:1399630 UCL Department / Division MRC Laboratory for Molecular Cell Biology Grade 7 Hours Full Time Salary (inclusive of London allowance) £32,699 - £39,523 inclusive per annum Duties and Responsibilities The Mao lab studies the mechanics of tissue growth and regeneration, combining genetics, in vivo live imaging, automated image analysis, experimental biophysics and computational modelling. Current projects in the lab include interdisciplinary approaches to study how mechanical forces affect tissue growth, tissue architectural changes, cell shape changes during mitosis and tissue regeneration in the Drosophila wing disc. We are looking for an experienced developmental or cell biologist to study the mechanics of in vivo 3D tissue growth, using initially the Drosophila wing as a model system. Available from March 2014, one post is offered for a period of three years in the first instance and the other for one year in the first instance. Key Requirements Candidates should possess / or shortly be awarded a PhD degree in biology, biophysics, or a related biological sciences discipline. A strong background in advanced live imaging, cell / tissue mechanics, quantitative image analysis, molecular and cell biology are required. Experience with Drosophila genetics, tissue mechanical measurements and tissue manipulation techniques are advantageous. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Ione Karney i.karney@ucl.ac.uk Highly committed candidates are encouraged to contact Yanlan Mao by email at y.mao@ucl.ac.uk. UCL Taking Action for Equality Closing Date 20 Feb 2014 Latest time for the submission of applications 5.00pm This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about the UCL Terms and Conditions related to this job, employee benefits that we offer and further information about UCL. Job description and person specification

Contrato postdoctoral dentro del programa del MINECO

Se ofrece la posibilidad de un contrato postdoctoral dentro del programa del MINECO (Subprograma Estatal de Formación, BOE nº313, 31 de diciembre de 2013) en una de las líneas de investigación activas en el Servicio de Micología, del CNM-ISCIII Proponemos la incorporación a un proyecto de investigación que contempla varias vertientes relacionadas. Por un lado nuestro grupo trabaja en el desarrollo y estandarización de métodos cromatrográficos relacionados con la monitorización de tratamientos, estudios farmacocinéticos en modelos animales, etc…y por otro, estamos desarrollando metodologías destinadas a evaluar variantes genéticas humanas y su relación con el metabolismo de antifúngicos. Buscamos un candidato que cumpla los siguientes requisitos: • Haber finalizado su tesis doctoral con posterioridad al 1 de septiembre de 2009. • Haber realizado la tesis doctoral en un OPI distinto al ISCIII • Tener gran motivación por la investigación • Acreditar publicaciones de nivel científico relacionadas con el campo del proyecto a desarrollar • Disponer de un buen nivel de inglés Es además muy valorable: • Experiencia demostrada en manejo de equipos HPLC • Experiencia en el manejo de software PK/PD • Experiencia en genética humana Más información sobre nuestro grupo en la siguiente dirección electrónica: http://www.isciii.es/ISCIII/es/contenidos/fd-el-instituto/fd-organizacion/fd-estructura-directiva/fd-subdirecciongeneral- servicios-aplicados-formacion-investigacion/fd-centros-unidades/fd-centro-nacional- Microbiologia/Publicientificas_Bacteriologia_Micologia_Parasitologia.pdf Los interesados han de enviar su CV a Alicia Gómez- López (aliciagl@isciii.es) antes del 11 de febrero de 2014. El plazo de presentación de solicitudes al MINECO es del 12 al 24 de febrero de 2014.

Postdoctoral Researcher

Comparative Cell Biology and Pharmacology of Disease Department of Comparative Biomedical Sciences Royal Veterinary College, Camden, London Salary: c. £31.1k pa inclusive Contract length: 2 years Closing Date: 4 March 2014 Job Ref: CBS-0008-14 Interviews: likely to be held the week beginning 24 March 2014 Topic: Metabolic defects in Neurodegeneration Job summary: Defects in mitochondria and lysosomes, which may result in a lack of specific metabolites, have been implicated in a variety of neurodegenerative diseases, including Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL), a paediatric progressive neurodegenerative disease that is the focus of this research. Aim The post is full time and the successful applicant will be responsible for running the experimental program outlined in the awarded grant. We will use the zebrafish model to determine whether defects in autophagy or mitochondria contribute to LINCL pathology and determine if nutritional supplements or upregulation of mitochondrial ATPsynthase Inhibitory Factor 1 (IF1) function ameliorates the neurodegenerative phenotype of the zebrafish model of LINCL, therefore indicating if this approach has potential for treating affected children. The team leaders Drs. Claire Russell and Michelangelo Campanella will provide training in the key techniques. Your profile Applicants must have a PhD in a biological science, experience using zebrafish or performing mitochondrial and autophagy assays, ability to troubleshoot and optimise experiments, and effective teamwork and communication skills, with a high degree of motivation. Informal enquiries to Dr Claire Russell crussell@rvc.ac.uk or Dr Michelangelo Campanella mcampanella@rvc.ac.uk The tentative start date for this role is June 2014. We offer a generous reward package including a pension scheme. For further information and to apply on-line please visit our website: www.rvc.ac.uk

miércoles, 5 de febrero de 2014

Postdoctoral positions NYC WCMC

McGraw lab - Biochemistry Postdoctoral position Project: Studies of insulin action in adipocytes. The work entails using molecular cell biological methods and quantitative fluorescence microscopy to dissect the mechanism by which insulin regulates the trafficking of the glut4 glucose transporter to the plasma membrane. This process is key for the regulation of whole body glucose homeostasis. The process is disrupted in insulin resistance and type 2 diabetes. The position is available immediately. Contact: temcgraw@med.cornell.edu McGraw lab - Biochemistry Postdoctoral position Project: Studies of the GIP incretin hormone system. GIP is a hormone produced by K-cells of the gastrointestinal track in response to food. GIP has a critical role in setting the tone of insulin response. The project entails using molecular cell biological methods and quantitative fluorescence microscopy to study the GIP/GIP receptor in cultured adipocytes. The position is available immediately. Contact: temcgraw@med.cornell.edu McGraw and Altorki Lab - Biochemistry and CT Surgery Postdoctoral position. Project: Studies of the roles of fibroblasts in lung cancer. The project entails using mass spectrometry and RNAseq methods to establish a pro-tumorigenic profile of tumor-promoting fibroblasts. The pro-tumorigenic profile will be validated and tested in cell-based and animal studies. The objective of this work is to identify fibroblasts activities that promote tumorigenic, with the long-term objective of developing methods to therapeutically target these activities. The position is available immediately. Contact: temcgraw@med.cornell.edu

Postdoc position in Marburg

The Institute of Pharmacology at the Biochemical-Pharmacological Center of the Uni- versity of Marburg (group of Prof. Dr. Thomas Worzfeld; www.bpc-marburg.de) invites applications for a Postdoc position in the field of Cancer Research and Pharmacology We are studying the biological roles of the semaphorin-plexin signaling system in can- cer and during epithelial organ repair (PNAS 2014; J. Clin. Invest 2012). We apply molecular and cellular biology techniques, biochemistry, advanced imaging, generation of constitutive and conditional mouse mutants, BAC transgenics in mice, and histology. We are seeking for an enthusiastic, highly motivated and creative scientist with a back- ground in molecular and cellular biology. Knowledge of mammalian physiology and ex- perience with mice and/or with advanced imaging techniques would be advantageous. We offer a dynamic working environment at the Biochemical-Pharmacological Center of the University of Marburg, one of the most beautiful old university towns in Europe, and a stimulating scientific surrounding in a young, international and motivated team. The position is immediately available. Applicants should send their statement of interest, a full CV and the name and address of at least two references to thomas.worzfeld@staff.uni-marburg.de.

Oferta posición postdoctoral

REQUISITOS: - Doctor en biología, farmacia, medicina, bioquímica, biotecnología, y/o otras relacionadas con el campo de la salud. - Experiencia post-doctoral. Dirección de tesis y coordinación de Becarios/Proyectos. - Curriculum competitivo con publicaciones preferentemente como primer, último autor o autor de correspondencia. El candidato ha de tener un mínimo de 4 publicaciones como primer, último autor o autor de correspondencia en revistas de alto impacto (1er cuartil) en los últimos 10 años. - Se requiere experiencia previa en obtención de financiación competitiva en el ámbito de la investigación fundamental o traslacional, en convocatorias de proyectos del Plan Nacional de I+D+i u otras convocatorias competitivas nacionales e internacionales. - Buen dominio de la lengua inglesa hablada y escrita. - Se requieren capacidades para ser responsable de un grupo de investigación o de una línea de investigación en colaboración con la clínica. Conocimientos y experiencia en ciclo celular y/o angiogénesis Técnicas básicas necesarias -PCR/real time/retrotranscriptasa - Electroforesis y secuenciación -Western Blott -ELISA -Inmunohistoquímica -Microscopía (Óptica, Fluorescente y Confocal) -Citometría de Flujo -Cultivo celular y/o Bacteriano ITEMS EXTRA VALORADOS: - Experiencia en investigación sobre tejido epitelial-mucosa. En especial estudios de histología y anatomía patológica - Experiencia en enfermedades inmunes, inflamatorias o infecciosas bacterianas ( I3) - Se tendrán en cuenta otras aportaciones de la investigación, incluyendo la transferencia de conocimiento: los libros o capítulos de libros científicos y técnicos. Así como las indicativas de la capacidad de gestión de I+D+i y de transferencia de tecnología: proyectos concedidos, patentes concedidas, patentes licenciadas, participación en contratos de colaboración, etc. Técnicas de laboratorio deseables -Cultivo de tejido o de células obtenidas de tejido -Clonación/transfección ADN -Northern y Southern Blott -DNA arrays -Inmunoprecipitación (IP) y coIP -2D y 3D electroforesis CARACTERÍSTICAS DEL PUESTO: - Dirección, desarrollo y coordinación de proyectos con carácter traslacional de investigación básica en estrecha colaboración con la clínica sobre enfermedad inflamatoria intestinal e infección por Helicobacter pylori - Contrato con altas posibilidades de permanencia - Ambiente académico activo y estimulante de elevada producción científica

Apply for a Postdoc Position at the CDC

http://emessaging.vertexcommunication.com/p/vJYdorr8nN Check Out ASM Professional Development Opportunities for Your Grad Students and Postdocs

Postdoctoral Research Scientist: Stromal Cell Immunology

Postdoctoral Research Scientist: Stromal Cell Immunology (Ref: OTL-2014-01). Orbsen Therapeutics is seeking a talented and experienced Immunologist to study role of stromal cells in controlling innate and adaptive responses to inflammatory disease. A PhD degree in Immunology and experience in developing transgenic models of disease are essential. Experience in flow cytometry, cell culture, lymphocyte function assays, QPCR, protein assays and histology are also highly desirable. Applications are invited from suitably qualified candidates for a full time EU FP7-funded, 3-year fixed-term position at Orbsen Therapeutics Ltd. in Galway, Ireland. Salary: EU €45,000-50,000 annually depending on skills and experience. The position is available to start February 17th 2014. Orbsen Therapeutics is Ireland's leading cell therapy company. We have identified, developed and patented a novel marker that enables best-in-class purification of therapeutic stromal cells from a variety of sources including bone marrow and umbilical cord. With 23 clinical, academic and commercial partners across Europe and the US, Orbsen is developing this cell therapy for the microvascular complications of diabetes (MCD), primary sclerosing cholangitis (PSC) and acute respiratory distress syndrome (ARDS). To apply please email: steve.elliman@orbsentherapeutics.com Please attach CV, Letter of Interest and 3 references Closing date: 24th February 2014 For further information, please contact (no agencies please): Steve Elliman. Head of R&D, Orbsen Therapeutics Ltd. Email: steve.elliman@orbsentherapeutics.com

Position available for application to the Spanish MINECO Postdoctoral Program

Eligibility criteria: •PhD defended between september 2009 and june 2014. •Candidates cannot be recipients of Ramón y Cajal or Juan de la Cierva fellowships from previous years, and cannot apply to the Ramón y Cajal Program this year. •Candidates can only apply for 1 research Institution. •Demonstrable experience in cellular and molecular biology and epigenetics is required. Experience on iPS cells, metabolism, massive sequencing, mice hematopoietic transplantation or mesenchymal stem cells is a plus. •A robust CV with 2-3 publications as first author in journals of impact factor >6 are required. •High scientific motivation, proactive attitude, communication skills and troubleshooting ability. The project will be performed at the Medicine School of the University of Barcelona / Josep Carreras Leukemia Research Laboratory (Pablo Menendez Lab. http://www.carrerasresearch.org/). The project will use different approaches (cell and molecular biology, genetics and epigenetics, animal models, cell reprogramming, drug testing) to gain insights into the developmental and molecular mechanisms underlying the pathogenesis of pediatric leukemias. Selected publications of the group: Rubio et al. Stem Cells 2014 Bueno et al. Cell Res 2012 Ramos-Mejía et al. Cell Res 2010 Montes et al. Leukemia 2014 Real P et al. Mol Ther 2012 Ramos-Mejía et al. Mol Ther 2010 Meyer et al. Leukemia 2013 Rodríguez et al. Cell Res 2012 Gutierrez-Aranda et al Stem Cells 2010 Bueno et al. Blood 2013 Sanchez et al. Stem Cells 2011 Rubio et al. Cancer Res 2010 Real et al. Blood 2013 Rodríguez et al. Stem Cells 2011 Menendez et al J Exp Med 2009 Rodríguez et al. Stem Cells 2013 Montes et al. Blood 2011 Bueno et al. Carcinogenesis 2009 Rubio et al. Oncogene 2013 Bueno et al. Leukemia 2011 Montes et al. Cell Res 2009 Chilón et al. Leukemia 2012 Barroso-delJesus et al. FASEB J 2011 Barroso-delJesus et al. Mol Cell Biol 2008 Ramos-Mejía et al. Trends Mol Med 2012 García-Pérez et al. Nature 2010 Bueno et al. Leukemia 2008