POSTDOCTORAL position Mitochondrial Physiopathology Laboratory

Mitochondrial Physiopathology Laboratory Instituto de Investigaciones Biomédicas Position available for application to the postdoctoral contracts to the MINECO Mitochondrial disorders (MD) are multisystem diseases that arise as a result of dysfunction of the oxidative phosphorylation system. In the laboratory, different lines of research have been developed to study cardiac dysfunction and physiopathology of mitochondrial diseases caused by mutations in mtDNA and through inter-genomic communication defects using cellular and animal models. Some papers of the group Clemente, P , Peralta, S , Cruz-Bermudez, A, Echevarria, L, Fontanesi, F, Barrientos, A, Fernandez-Moreno, MA , Garesse, R . (2013). hCOA3 stabilizes COX1 and promotes cytochrome c oxidase assembly in human mitochondria. J. Biol. Chem. . (PMID: 23362268). Fernandez-Moreno, MA., Hernández, R, Adán, C , Roberti, M, Bruni, F, Polosa, PL, Cantatore, P, Matsushima, Y, Kaguni, LS, Garesse, R . (2013). Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1. Biochim. Biophys. Acta. 1829(10): 1136- 1146 (PMID: 23916463). Peralta, S. , Clemente, P. , Sánchez, A. , Calleja, M. , Hernández, R. , Matsushima, Y. , Adán, C. , Ugalde, C. , Fernández- Moreno, MÁ. , Kaguni, LS. , Garesse, R. , (2012). Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. J. Biol. Chem. 287(29): 24174-24185. Sanchez-Martinez, A. , Calleja, M. , Peralta, S. , Matsushima, Y. , Hernandez-Sierra, R. , Whitworth, AJ. , Kaguni, LS. , Garesse, R. , (2012). Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS ONE. 7(8). Arredondo, JJ. , Gallardo, ME. , García-Pavía, P. , Domingo, V. , Bretón, B. , García-Silva, MT. , Sedano, MJ. , Martín, MA. , Arenas, J. , Cervera, M. , Garesse, R. , Bornstein, B. , (2012). Mitochondrial tRNA valine as a recurrent target for mutations involved in mitochondrial cardiomyopathies. Mitochondrion. 12(2): 357-362. Eligibility Hold a postdoctoral degree after September 2009 (in a different Centre) First author publication in an international peer reviewed journal If you are interested, please send a letter explaining your experience, your interest and your CV to: Rafael Garesse (rafael.garesse@uam.es)