candidates for a two years postdoc contract

We look for candidates for a two years postdoc contract (“Contratos para la formación posdoctoral ” BOE. December 31st 2013. Deadline March 3rd 2014 ). The work will be in the group of “Extracellular Matrix Remodeling in the Cardiovascular System” at the Centro de Biología Molecular Severo Ochoa, Madrid, Spain. The formation and assembly of extracellular matrix componentes is a fundamental process to maintain the integrity of the connective tissue, and therefore, extracellular matrix alterations are associated with some diseases, including Marfan or Ehlers‐Danlos Syndromes, as well as with fibrotic disorders including idiopathic pulmonary fibrosis, liver cirhosis, systemic sclerosis, etc. By using in vivo and in vitro approaches, we study the molecular mechanisms governing the development of extracellular matrix‐related disorders and explore new therapeutic approaches for the clinical treatment. Recent publications: 􀂙Busnadiego, O., González‐Santamaría, J., Lagares, D., Guinea‐Viniegra, J., Pichol‐Thievent, C., Muller, L. and Rodríguez‐Pascual, F. 2013. LOXL4 is induces by TGF‐β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling. Molecular and Cellular Biology, 33: 2388‐2401. 􀂙Lagares D, Busnadiego O, García‐Fernández RA, Kapoor M, Liu S, Carter DE, Abraham D, Shi‐Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM, Leask A, Lamas S, Rodríguez‐Pascual F. 2012. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis & Rheumatism, 64: 1653‐1664. 􀂙Lagares D, García‐Fernández RA, Jiménez CL, Magán‐Marchal N, Busnadiego O, Lamas S, Rodríguez‐Pascual F. 2010. Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. Arthritis & Rheumatism, 62: 878‐889. Please contact with: Fernando Rodríguez Pascual Email: frodriguez@cbm.csic.es Tel. +34 911964505 Web: http://web4.cbm.uam.es/joomla‐rl/index.php/en/scientific‐departments/cell‐biologyand‐ immunology?id=%20523 Analysis of the subcellular localization of the isoform 4 of lysyl oxidase (LOXL4) fused to greeen fluorescent protein in aortic endothelial cells. Colocalization with the endoplasmic reticulum marker (confocal microscopy). LOXL4-GFP ER marker: CALNEXIN