Contrato Programa Ramón y Cajal

Contrato Programa Ramón y Cajal Se ofrece la posibilidad de solicitar un contrato postdoctoral del Programa Ramón y Cajal (5 años) en el Instituto Cajal-CSIC (Madrid) para un investigador con experiencia dispuesto a realizar estancia postdoctoral trabajando en cualquiera de las líneas de investigación de nuestro laboratorio sobre “Nanomecánica de proteínas sinápticas y sinaptopatías”. El candidato seleccionado se integrará en un ambiente de trabajo estimulante y en un momento extraordinariamente productivo del laboratorio. Se dispone de la co-financiación requerida procedente de proyectos europeos. Fecha límite: 4 de Febrero de 2014. Requisitos Doctor (grado de doctor posterior al 1.1.2003) en Ciencias (Físicas, Química, Biología, Bioquímica, Biotecnología o Farmacia). Buscamos un candidato muy motivado que quiera continuar su carrera científica y posea al menos cinco publicaciones de primer autor en revistas internaciones de referencia de alto impacto. El laboratorio de nanomecánica de proteínas Nuestro laboratorio tiene una fuerte componente multidisciplinar que combina la microscopía de fuerza atómica con la ingeniería de proteínas, la biología estructural, la dinámica molecular, el uso de modelos animales (células, Drosophila y ratón) para entender el mecanismo de acción de las proteínas en las funciones neurales. Los estudios se llevarán a cabo en el Instituto Cajal, una institución pionera y líder de la investigación en Neurobiología situada en el centro de Madrid, y el IMDEA Nanociencia, un nuevo instituto situado en la UAM. En nuestro laboratorio estamos interesados en los mecanismos moleculares responsables de la consolidación de la memoria, la neurodegeneración, adhesión celular y la fusión de membranas. Nuestras líneas de investigación están enfocadas en la nanomecánica del CPEB (prionoide descubierto por E. Kandel que controla la consolidación de memoria), las proteínas neurotóxicas (agentes causales de las enfermedades neurodegenerativas), el proteasoma, las proteínas de scaffolding, las cadherinas sinápticas y auditivas, y el complejo SNARE. El campo: la Nanomecánica de Proteínas Las proteínas se encargan de la inmensa mayoría de las funciones biológicas y son consideradas en la actualidad como bionanomáquinas cuyo funcionamiento interno está siendo desvelado por las técnicas monomoleculares (bioquímica de moléculas individuales). La nanomanipulación es una de ellas que permite la aplicación de fuerzas mecánicas a moléculas individuales empleando así la fuerza mecánica como un nuevo parámetro bioquímico. Como resultado de ello, la nanomecánica de proteínas ha emergido en poco más de una década como un campo extraordinariamente activo que estudia las propiedades mecánicas de las proteínas. La microscopía de fuerza atómica es una de las técnicas más utilizadas en el campo, de una gran utilidad particularmente para el estudio de las proteínas con función mecánica y las proteínas desestructuradas (como las neurotóxicas o el prionoide CPEB). Solicitudes Dirigid vuestras solicitudes (incluyendo CV y el expediente académico) a Mariano Carrión Vázquez (mcarrion@cajal.csic.es). Dpto. de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal/ CSIC. Avda. Doctor Arce 37, 28002 Madrid. Publicaciones representativas PLoS Biol. 10(5):e1001335 (2012). Curr Opin Struct Biol 20, 63-69 (2010); Proc Natl Acad Sci USA 106,13791-6 (2009); J Biol Chem 283, 6617-21 (2008), Investigación y Ciencia 370, 45-53 (2007), Nature Str Biol 10, 738-43 (2003). Página Web: http://www.cajal.csic.es/departamentos/carrion-vazquez/carrion-vazquez.html

Postdoctoral position

A postdoctoral position is available in the Department of Molecular Biology (www.molbiol.umu.se ) at Umeå University, Sweden to study the mechanisms and control of mRNA stability in yeast.Projects include (but not limited to) studying potential relationships between mRNA degradation, RNA granules and aging as well as using a computational approach the examine the function of RNA granules. Highly motivated candidates with a strong interest in RNA biology are encouraged to apply. Candidates should have a PhD in Biochemistry, Molecular Biology, or related fields, strong technical and communication skills, and an established publication record. Past experience working with RNA is an asset. If you are interested in joining our research team, please visit our web site (www.mrna-lab.org ) for additional information. Interested candidates should send a CV, contact details for two references and a research statement describing research interests and career goals to Tracy Nissan, tracy.nissan@molbiol.umu.se

PhD-student position in Functional Zoomorphology

PhD-student position in Functional Zoomorphology at the Department of Zoology, Stockholm University. Reference numbers FV-0090-14. Application deadline: February 15, 2014 Project: Role of insulin signaling in development and ageing processes in Drosophila We are seeking a PhD student in Neuroscience/ Functional Zoomorphology to be active in the research project “Role of insulin signaling in development and ageing processes in Drosophila”. This will be affiliated with a larger project (”Insect life cycle genomics and adaptation in the wild”) with financial support from the Knut & Alice Wallenberg Foundation and the Swedish Research Council. The specific project will use the fruitfly Drosophila as a model. The studies involve genetic, molecular and endocrinological analysis of insulinregulated processes that affect cell growth and maintenance, as well as effects on senescence. Part of the project will be in collaboration with researchers studying the effect of reproductive dormancy (diapause) on lifespan and aging in the larger project mentioned above. Qualification and competence To be qualified for research studies in functional morphology the applicant must have completed a research degree (e.g. Master’s), or have passed at least 120 hp (2 years) of biological studies, including an approved independent project of at least 30 hp at advanced level (“examensarbete”) within functional zoomorphology or a related subject such as animal physiology, genetics, cell- and molecular biology. Applicants, who have in principle acquired the corresponding competence in Sweden, or abroad, are also qualified. Criteria for selection: Among qualified applicants, selection is made according to the ability to profit from the studies. The criteria to be used are properly documented competence within the described research area, capabilities with regards to speaking and writing in English (and Swedish, when relevant), analytical thinking, creativity, initiative, independence, and team work performance. The applicant’s earlier experience within the field of research can be of relevance especially when further documented by university courses, independent research works, personal references, interview and an application indicating the applicant’s motivations in written form. The application should contain: 1) maximum one A4-page of personal presentation and letter of intent/motivation, 2) CV (including methodological skills), 3) Copy of independent project thesis, 4) Copies of degree certificates and transcripts of academic records (attested), 5) Contact details for two academic referees. Job details: The PhD-studies include 48 months of full-time studies with employment as PhD student. Contact for further details: Prof. Dick R. Nässel +46-8 164077, dnassel@zoologi.su.se Official union representatives: Anqi Lindblom-Ahlm, SACO, Lisbeth Häggberg, ST (08- 162000) and Gunnar Stenberg, SEKO (070-3164341). Application In order to apply for this position, please use the Stockholm University web-based application form. Welcome with your application no later than February 15, 2014.

Image Analysis Position in Paris

Our team studies emerging questions in the field of tissue dynamics and cytoskeletal mechanics (http://www.ugbdd.curie.fr/en/article/00219-polarity-division-and-morphogenesis). We are hiring an Engineer in Image Analysis to analyse large time-lapse microscopy datasets and develop novel cell descriptors, cell segmentation and cell tracking methods. ur team is interdisciplinary, composed of both biologists and physicists, and is located in the Department of Developmental Biology and Genetics of the Curie Institute, Paris, France. > > Missions > · Design software tools for quantitative image analysis and treatment: Intracellular protein distribution analysis, shape recognition, cell/particle tracking, segmentation, etc… > > · Collaborate with researchers by developing/implementing algorithms to solve problems related to image-processing in microscopy of biological systems (cell and tissue levels). > > · Collaborate with biologists and physicists of the team, as well as with our collaborators in bioinformatics for image analysis and modeling in biology. > > Skills > > · University degree (Master degree or, ideally, a PhD) or engineer school in Physics, Computer Science, Mathematics or equivalent qualification, specialized in image treatment and analysis. > > · Proven experience applying and/or developing image analysis tools using ImageJ, MATLAB, or directly in Java or equivalent programming language (C++, Python, etc). > > · Strong experience in image analysis and processing is required or in soft matter physics. > > · Knowledge of segmentation algorithms, tracking and shape recognition is mandatory. > > · Experience with methods in statistics is a plus. > > · Experience in advanced light microscopy is welcome but not required. > > · Ability to work in a team. > > · Ability to manage projects with a high degree of autonomy is necessary. > > · Must be able to communicate in English. > > Contact: Please send your CV and relevant documents to: yohanns.bellaiche@curie.fr > > Contract: A three-year contract. Salary – Depends on experience and qualification

PhD fellowship

We are urgently seeking candidates to fill a position for a PhD fellowship funded by the ENC (European Neuroscience Centers) we have available jointly with Guus Smit Laboratory in Amsterdam. The project will be 2/3 in Bordeaux and 1/3 in Amsterdam. This project aims to the characterization of new auxiliary AMPAR protein and the respective role of this protein and Stargazin using cell biology, high resolution imaging and physiology. The full application can be seen on the ENC website (www.enc-network.eu[1]) Candidate master2 students from your university have to put their applications on the ENC site _BEFORE FEBRUARY 7TH._

Spanish MINECO Postdoctoral Program

Spanish MINECO Postdoctoral Program Marisa Toribio’s Group Human Hematolymphoid Development Department of Cell Biology and Immunology Centro de Biología Molecular Severo Ochoa. CSIC-UAM. Madrid We are seeking postdoctoral candidates interested in joining our research group under the Spanish MINECO Postdoctoral Program. Our main line of research is the study of the cellular and molecular mechanisms that control the physiological development of human T lymphocytes and the generation of acute leukemia. Our work is based on cell and molecular biology, genomics and animal model-based approaches. Specific Information about this postdoctoral call can be found at BOE of Dec 31 2013 (page 107239). The deadline for this application is February 8, 2014. Eligibility criteria include: (i) Ph.D. degree at the moment of contract. (ii) Ph.D. thesis defended later than Sept 1, 2009. (iii) Ph.D. carried out outside the CBMSO. (iv) Publication record. We are looking for an organized, enthusiastic and committed candidate with experience in cell and molecular biology techniques. It would be advantageous to have experience in animal models and practical knowledge of English. Please send your CV, letter of motivation (up to one page) and the names of 2 references via email to mtoribio@cbm.uam.es Further information on our group is available at http://www2.cbm.uam.es/mkfactory.esdomain/webs/cbmso/plt_LineasInvestigacion.aspx?IdObjeto=27

Contrato postdoctoral dentro del programa del MINECO 2+2

Se ofrece la poslblfldad de un contrato postdoctoral en el grupo del Dr. sergio Moreno, en e/Instituto de Biología Funcional y fif.l19l11ir¡, de Salamanca dentro del programa del MINECO 2+2 (BOE 3111212013, p. (07264). Nuestro grupo trabaja en crecimiento, división y diferenciación celular y empleamos la levadura ~,h~OM;J

POSICIÓN POSTDOCTORAL

CENTRO DE INVESTIGACIÓN DEL CÁNCER (CSIC-UNIV. de SALAMANCA) POSICIÓN POSTDOCTORAL MECANISMOS MOLECULARES DE LA AUTOFAGIA CELULAR Y SU IMPLICACIÓN EN CÁNCER, INMUNIDAD INNATA E INFLAMACIÓN. MODELOS ANIMALES. DIRIGIDO A: Doctores en Biociencias que tengan vocación investigadora y CV competitivo. Se solicitará contrato postdoctoral del MINECO en su convocatoria de 2014. Es necesario haber obtenido el Doctorado con posterioridad al 1 Sept. 2009 CONTACTO: Dr. Felipe X. Pimentel Centro de Investigación del Cáncer CSIC-Universidad de Salamanca Teléfono: 923-294818 e-mail: fxp@usal.es FECHA LÍMITE: 15 de Febrero de 2014

Group Leader Positions at the Institut Curie

The Unit of Physico-Chemistry Curie (PCC) at the Institut Curie, a world-class multidisciplinary cancer research center, is recruiting outstanding young scientists for independent Research Group Leader positions. Group Leader Positions Unit of Physico-Chemistry, Institut Curie, Paris Motivated candidates should submit a complete CV; a summary of scientific achievements (1-2 pages); a one-page summary of their research objectives; and a more detailed five-year research plan (10 pages maximum). The complete application should be addressed to Dr. Maxime Dahan, the director of the PCC unit, and sent (as a single pdf file) to:recruitment.pcc@curie.fr. In addition, three letters of reference should be sent directly by referees to the above email address. Applications will be accepted until March 15, 2014. Pre-selected candidates will be invited for interviews in early June 2014. Further information is available at: http://umr168.curie.fr The PCC unit is a research department gathering physicists, chemists and biologists interested in the study of the biophysical principles underlying the architecture and functions of biological systems. Our department has a longstanding tradition of combining theoretical approaches with advanced experimental techniques. Current research embraces a multi-scale approach ranging from single molecules (molecular motors, DNA-protein interactions, membrane proteins) to cellular functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behavior of cells in tissues (wound healing, morphogenesis). We encourage applications in all areas complementary to our current research portfolio. New investigators with interest in the biophysics of nuclear organization and functions, or the biophysics of multicellular systems are particularly welcome. The department benefits from the highly stimulating scientific environment offered by an internationally renowned institute combining fundamental and clinical research, and from its attractive location in central Paris, in close proximity to other major research centers. Successful candidates are expected to have a significant track record in research. An initial start up package will be provided to allow competitive candidates to apply for grant funding and permanent positions within French research institutions (CNRS, INSERM, University).

POSTDOCTORAL position Mitochondrial Physiopathology Laboratory

Mitochondrial Physiopathology Laboratory Instituto de Investigaciones Biomédicas Position available for application to the postdoctoral contracts to the MINECO Mitochondrial disorders (MD) are multisystem diseases that arise as a result of dysfunction of the oxidative phosphorylation system. In the laboratory, different lines of research have been developed to study cardiac dysfunction and physiopathology of mitochondrial diseases caused by mutations in mtDNA and through inter-genomic communication defects using cellular and animal models. Some papers of the group Clemente, P , Peralta, S , Cruz-Bermudez, A, Echevarria, L, Fontanesi, F, Barrientos, A, Fernandez-Moreno, MA , Garesse, R . (2013). hCOA3 stabilizes COX1 and promotes cytochrome c oxidase assembly in human mitochondria. J. Biol. Chem. . (PMID: 23362268). Fernandez-Moreno, MA., Hernández, R, Adán, C , Roberti, M, Bruni, F, Polosa, PL, Cantatore, P, Matsushima, Y, Kaguni, LS, Garesse, R . (2013). Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1. Biochim. Biophys. Acta. 1829(10): 1136- 1146 (PMID: 23916463). Peralta, S. , Clemente, P. , Sánchez, A. , Calleja, M. , Hernández, R. , Matsushima, Y. , Adán, C. , Ugalde, C. , Fernández- Moreno, MÁ. , Kaguni, LS. , Garesse, R. , (2012). Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. J. Biol. Chem. 287(29): 24174-24185. Sanchez-Martinez, A. , Calleja, M. , Peralta, S. , Matsushima, Y. , Hernandez-Sierra, R. , Whitworth, AJ. , Kaguni, LS. , Garesse, R. , (2012). Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS ONE. 7(8). Arredondo, JJ. , Gallardo, ME. , García-Pavía, P. , Domingo, V. , Bretón, B. , García-Silva, MT. , Sedano, MJ. , Martín, MA. , Arenas, J. , Cervera, M. , Garesse, R. , Bornstein, B. , (2012). Mitochondrial tRNA valine as a recurrent target for mutations involved in mitochondrial cardiomyopathies. Mitochondrion. 12(2): 357-362. Eligibility Hold a postdoctoral degree after September 2009 (in a different Centre) First author publication in an international peer reviewed journal If you are interested, please send a letter explaining your experience, your interest and your CV to: Rafael Garesse (rafael.garesse@uam.es)

56ª CONVOCATORIA DE BECAS FULBRIGHT

*56ª CONVOCATORIA DE BECAS FULBRIGHT DE AMPLIACIÓN DE ESTUDIOS EN LOS ESTADOS UNIDOS DE AMÉRICA PARA TITULADOS SUPERIORES EN CUALQUIER CAMPO DE ESTUDIO, CURSO 2015-2016* La Comisión de Intercambio Cultural, Educativo y Científico entre España y los Estados Unidos de América convoca hasta un máximo de 25 becas Fulbright destinadas a titulados superiores que estén interesados en programas de /Master's/, /Ph.D. /o, excepcionalmente, en proyectos//de investigación predoctoral en una universidad estadounidense durante el curso académico 2015-2016. *Fecha límite de presentación de solicitudes:* *10 de marzo de 2014. * *Dotación* para: viaje, compra de libros y materiales; manutención; matrícula; seguro médico y de accidentes. *Patrocinadores: *Gobiernos de España y de Estados Unidos, Junta de Andalucía, Comunidad de Madrid, Universidad de Maryland-Baltimore County, Abengoa, Abertis, Asociación de Exbecarios J.W. Fulbright, Caldwell-Fiscer Charitable Foundation, Coach, Coca-Cola, El Corte Inglés, Fundación Ramón Areces, Grifols, Iberdrola, Mapfre, Repsol, Telefónica. *Impreso de solicitud:*En el siguiente enlace de la página web de la Comsion Fulbright. *Más información: * Página web: _www.fulbright.es_ Asesoría Académica:enlace para solicitar información Tel.91-319-1126 adviser@comision-fulbright.org Comisión de Intercambio Cultural, Educativo y Científico entre España y los Estados Unidos de América Calle General Oráa, 55. 28006 Madrid

Position available for the Spanish Postdoctoral Programme

CSIIC--USAL Position available for the Spanish Postdoctoral Programme (2+2 yeras, BOE 13, December 2013) Centtrro de IInvesttiigaciión dell Cáncerr Our main focus is to understand the involvement of chromosome segregation in human disease. We are particularly interested in chromosome instability and human infertiity and carcinogenesis. •We use multidiscilpinar approaches including the development of novel mouse genetic models, exome sequencing of human pedigrees, proteomics and 3D microscopy. -Eligibility criteria -PhD Thesis before 1st September 2009. -Predoctoral training out of Salamanca´s campus. -Highly motivation. -Publication record. Interested should send CV before February 8, 2014 to: • Alberto M. Pendás Centro de Investigación del Cáncer 37007 Salamanca, Spain •Phone 34 923 29 48 09 • E-mail: amp@usal.es »Selected Publications of the group: Llano et al., Genes and Dev. 2008 Herrán et al., EMBO J 2011 Llano et al., J Cell Biol 2012 Gutiérrez-Caballero et al., Trends in Genetics 2012 Caburet et al., New Engl J Med. 2014 In press

Research group leaders offer in the Institute of Molecular Biology (IMB) in Mainz

The Institute of Molecular Biology (IMB) in Mainz is looking for research group leaders active in the fields of DNA repair, Epigenetics/RNA/Chromatin, and Nuclear Cell Biology (i.e. interested in next-generation sequencing, advanced light microscopy, molecular cell biology, biochemistry, genetics and computer simulations). Positions are for five years initially, and can be renewed. The IMB is located within the campus of the Johannes Gutenberg University Mainz and is funded by the Boehringer Ingelheim Foundation. There are no teaching obligations, but teaching opportunities are available at the University of Mainz. The deadline for applications is March 28th, 2014; interviews will take place on May 8th and 9th, 2014, in Mainz. For additional information, please visit https://www.imb-mainz.de/fileadmin/user_upload/_temp_/Research_Group_Leader2_CNRGL05.pdf

Academic Track Lecturers

Academic Track Lecturers Vacancy Ref : 024310 Department : Division Of Pathway Medicine Grade/Pay Scale : Ue08 (£37,756 - £45,053) Position Type : Full Time Date Posted : 10-Jan-2014 Closing Date : 10-Feb-2014 Employment Category : Fixed Term Vacancy Details Academic Track Lecturers Vacancy Ref: : 024310 Closing Date : 10-Feb-2014 Contact Person : Prof Sue Welburn Contact Number : Contact Email : Sue.Welburn@ed.ac.uk The University of Edinburgh is an exciting, vibrant research-led academic community offering opportunities to work with leading international academics whose visions are shaping tomorrow’s world. The School of Biomedical Sciences is mostly located in the central George Square area, hosting the Centre for Integrative Physiology (CIP), the Centre for Neuroregeneration (CNR), the Centre for Cognitive and Neural Systems (CCNS) and the Division of Pathway Medicine (DPM). We wish to appoint a new Lecturer to support teaching and research in the School of Biomedical Sciences in the area of Medical Microbiology. The post-holder will be expected to develop, deliver and assess undergraduate and postgraduate courses and contribute to the academic administration of teaching activities. Individuals will be expected to deliver an independent research programme that complements research priorities within the School of Biomedical Sciences, as evidenced by publications in leading international peer-reviewed journals and the ability to obtain external grant funding. The post requires a degree and a PhD in a subject related to Medical Microbiology. Experience in teaching in a Higher Education Institution would be a requirement. This post is for five years, subject to a review at the end of year three. It is intended that the post-holder will then move to a standard University academic open-ended contract at the end of year five. Applications should be made online at www.jobs.ed.ac.uk to meet the closing date below. CANDIDATE INFORMATION This post is aimed at early career individuals of the highest potential who have begun to establish a reputation for quality research in the field of Medical Microbiology and who have a proven commitment to university level learning and teaching. It is essential that the successful candidate’s research furthers the reputation of the Research Centre and the University and that she or he has a strong commitment to postgraduate and undergraduate training. The post is for a fixed term of 5 years, subject to satisfactory formal review at the end of year 3. At the end of the 5 year period the post-holder will transfer to an open-ended lectureship if performance standards are maintained. The post is available with immediate effect and it is expected that successful applicant will be in post by no later than May 2014. Limited start-up research funds might be available appropriate to the discipline. The post-holder will be mentored towards gaining research grant support and in the development of teaching and administration expertise. A sufficient amount of teaching and administration will be required in the first 3 years to allow a judgement to be made on continuation to a full academic position. Individuals with postdoctoral experience would normally be appointed at Grade 8. Exceptionally, an appointment at Grade 9 may occur for someone with extensive experience of research leadership. The Grade of appointment will be reviewed at the end of 3 years. The University’s generic Academic Grade 8 profiles states: Roles at this level are held by individuals experienced in research and/or teaching. In some cases, the contribution spans research and teaching. In others there may be a concentration on one or the other. In all cases, there will normally be accountability for the design, delivery and quality of at least a whole course, small research project or part of a larger research project, with measurable outcomes, as well as for contributing to the development of wider programmes/portfolios, supervising doctoral students or developing more high quality teaching. There may be responsibility for representing the work of the University in the specific field locally and nationally in appropriate networks and/or in public engagement activities and for contributing to the wider academic community beyond the University. Applications containing a detailed CV, a 1-page outline of a proposed research programme and a concise statement explaining teaching experience should be made online at www.jobs.ed.ac.uk to meet the closing date. In addition to the formal interview, all interviewees will be required to give a presentation to the panel and further information will be provided along with the invitation to interview. Applicants who wish to discuss specific issues about the posts and research interests should contact Professor Sue Welburn (Sue.Welburn@ed.ac.uk). Job Purpose To develop, deliver and assess undergraduate and postgraduate courses at the University of Edinburgh. Deliver an independent research programme that complements research priorities within the School of Biomedical Sciences, evidenced by publications in leading international peer-reviewed journals and the ability to (or potential to) obtain external grant funding. Contribute to the academic administration of teaching activities, including taking a role as a Personal Tutor and, once established, undertake further duties such as course or programme organiser. Contribute to the development of new teaching and research opportunities in a specific discipline within Biomedical Sciences. Main Responsibilities Approx. % of time 1. Organise, deliver and assess undergraduate and postgraduate courses within own and related subject areas to allow the School to deliver required teaching. 35% 2. Contribute to the academic administration of teaching activities to ensure the continual development of the course and maintain synergies with other courses. 10% 3. Provide academic support and advice to students by being a Personal Tutor. 5% 4. Deliver an independent, externally-funded research program. 40% 5. Supervise and assess undergraduate and MSc dissertations. Once established in post, supervision of PhD students. 10% Planning and Organising Set own objectives and plan own workload over the short-term (weekly) and long-term (annual), within the broad framework set by line manager. Prepare course material and teaching so that they are delivered at the correct level and within relevant deadlines. Undertake specific co-ordinating roles with other course organisers and lecturers to ensure delivery of programme, courses and assessments. Contribute to the development of teaching materials and innovative assessment methods. Establish and manage a program of research, including identification of suitable funding opportunities. Problem Solving Negotiate and resolve difficulties in promoting collaborative activities across university academic units and beyond in developing undergraduate teaching. The significant application of prior knowledge and accumulated expertise to solve unique research problems. An enhanced level of initiative and problem solving approach is needed to develop new techniques and novel approaches in response to emerging research issues. Ensure that innovative teaching materials and assessment methods developed for the current academic year are adapted to accommodate increases in student numbers in future years. Actively assess and monitor the rate at which each student can learn new skills and adapt existing skills. Decision Making Decide on prioritisation of own work and set own targets within a broadly-agreed strategy. Responsible for the majority of decisions relating to the research programme including devising an appropriate experimental strategy, prioritising experiments and deciding when and where to publish research results. Appropriate acquisition of research-related equipment and consumables to ensure the smooth running of a research group. Manage the supervision of postgraduate students and mentorship of junior project staff. Construct appropriate assessment for courses. Decide on changes to course content in relation to feedback from students, staff and External Examiners. Raise issues of concern directly with students and to know when/if to contact colleagues for advice. Key Contacts/Relationships Develop and maintain relationships with key academics in UoE working in areas relevant to main responsibilities. Form and maintain contacts with the relevant external research community. Liaise with course administrator to ensure the efficient and effective running of courses and make sure that the most appropriate course framework (documentation, timetable) is put in place for each year. Interact with other academic staff and School management, over course design, content and the identification of staff who will contribute to the course. Liaise with the Programme Organisers over the development of course material across the School of Biomedical Sciences. Negotiate with external partners and funders to agree contributions and potential cross-over collaborations and knowledge transfer events. Person Specification The post requires a PhD (or equivalent) in Medical Microbiology or a related Biomedical Sciences discipline. Experience in teaching in a Higher Education Institution with evidence of innovation in teaching delivery and assessment. Proven track record in research, evidenced by publications in leading international journals and evidence of obtaining (of having the capability to obtain) external research funding. Extensive experience of developing and applying theory, models, techniques and analytical methods as appropriate to the field of research. Good project management skills and experience of co-ordinating resources other than self (e.g. people, budgets) Excellent communication, presentation and organisational skills. A postgraduate teaching qualification would be desirable. Dimensions The post has a direct relationship with all aspects of the remit of the Biomedical Teaching Organisation (BMTO) particularly with respect to the development of teaching and learning for undergraduate and postgraduate degree programmes. With the current strategic plans leading to an increase in BSc Medical Sciences numbers, assuming responsibility for entire four years of BSc Biomedical Sciences programmes and continuing delivery of intercalating programmes the BMTO will be responsible for approximately 1100 undergraduate students and 300 taught postgraduate students. The post holder must be able to deliver teaching at all levels in Medical Microbiology especially in the area of bacteriology and host defence. The post holder will be expected to establish and maintain a program of research in Medical Microbiology or related area relevant to the School of Biomedical Sciences or other Schools in the College of Medicine & Veterinary Medicine. Job Context and any other relevant information With current plans to increase student numbers and requirements to ensure effective and efficient teaching in an environment that enhances the student experience this post is of critical importance to the School, College and wider University. Pension Scheme This role is grade UE08 and therefore the post holder is automatically included in membership of the Universities Superannuation Scheme (USS), subject to the USS membership criteria, unless they indicate that they choose not to join the Scheme. For further information please visit our Pensions website. Salary The role is grade UE08 and attracts an annual salary of £37,756 - £45,053 for 35 hours, each week. Salary is paid monthly by direct transfer to your Bank or Building Society account, normally on the 28th of the month. Salaries for part-time staff are calculated on the full-time scales, pro-rata to the Standard Working Week. This post is available on a fixed term basis, for 60 months. Application Procedure All applicants should apply online via our Vacancy Website. The application process is quick and easy to follow, and you will receive email confirmation of safe receipt of your application. The online system allows you to submit a CV and other attachments. Closing date: 10 February 2014 at 5pm. We anticipate interviews will be held in 1 to 2 weeks after closing date. You will be notified by email whether you have been shortlisted for interview or not. Eligibility to Work In accordance with the Immigration, Asylum and Nationality Act 2006 the University of Edinburgh, as an employer, has a legal responsibility to prevent illegal working and therefore must check that all employees are entitled to work in the United Kingdom (UK). To do so, the University of Edinburgh requires to see original documents evidencing right to work in the UK before commencement of employment and this is normally carried out at interview. Details will be provided in any letter of invitation to interview. For further information on eligibility to work please visit our eligibility to work website This post meets UK Border Agency criteria for sponsorship by the University of Edinburgh. Even if you are not currently eligible to work in the UK, it may be possible for the University of Edinburgh to sponsor you to obtain a Tier 2 (General) visa to enable you to take up the appointment should you be successful at interview. For applicants interested in sponsorship information is available on our Working in the UK website However, if you have previously been sponsored by an employer within the UK but your leave has expired or lapsed and you are no longer in the UK, according to UK Border Agency rules you can cannot apply for sponsorship under any category of Tier 2 for a period of 12 months after the date your leave has expired or lapsed. The University reserves the right to vary the candidate information or make no appointment at all. Neither in part, nor in whole does this information form part of any contract between the University and any individual. Division of Pathway Medicine The Division of Pathway Medicine (DPM) is a research centre in the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Division was officially formed on 1st February 2007 following the success and growth of the Scottish Centre for Genomic Technology and Informatics (GTI). The new division builds on the work of GTI and incorporates the activities of new investigators who joined the centre in 2006. The Division has already proved itself successful in obtaining funding for projects in new areas of research. We are conducting pioneering research programmes in: • Pathway Biology of Infection and Immunity - the study of host-pathogen interaction in immune cells and the modeling of molecular pathways that control immune cell function in health and disease. • Biochip Medicine in Systemic response to disease - the development of advanced biochip techniques and platforms for translating genomic and pathway research into clinical healthcare. The central goal of the Division of Pathway Medicine is to integrate post-genomic science with medicine in order to provide a better understanding of disease processes. This will provide the basis for the development of new medical innovations for the diagnosis and treatment of human diseases. http://www.ed.ac.uk/schools-departments/pathway-medicine The School of Biomedical Sciences The School of Biomedical Sciences (SBMS), which is headed by Professor Gareth Leng, employs around 220 staff mostly located in the central George Square area. The School hosts the Centre for Integrative Physiology (CIP, Head: Professor Mike Shipston), the Centre for Neuroregeneration (CNR, Head: Professor Peter Brophy), the Centre for Cognitive and Neural Systems (CCNS, Director: Professor Richard Morris FRS) and the Division of Pathway Medicine (DPM, Head: Professor Peter Ghazal) and also has strong links with Edinburgh Infectious Diseases (EID, Head: Professor Rick Maizels). Research themes within the School include: Genes and Development; Membrane Biology; Neural Control Systems; Cognition, Learning and Synaptic Plasticity; Neuropharmacology; Basic and Clinical Virology; and Bacterial Pathogenesis and Chemotherapy. Also within the School is the Biomedical Teaching Organisation (BMTO) which plays a vital role in the administration, coordination and implementation of undergraduate and postgraduate teaching. The BMTO is responsible for the BSc Medical Sciences programme, twelve BSc Biological Sciences Honours Programmes, eight Bachelor of Medical Sciences Honours programmes, four BSc Veterinary Sciences Honours Programmes and fourteen Biomedical Sciences courses delivered to first to third year undergraduates. In addition the BMTO has responsibility for the taught postgraduate programmes run by the School. The School is located across a number of sites: the Chancellor’s Building and Queen’s Medical Research Institute at Little France; the Medical School extension in Teviot Place; the Hugh Robson Building, George Square; No 1 George Square and the Ashworth Building at Kings Buildings. In RAE 2008, our staff were entered in 2 main categories of assessment. In Neuroscience & Psychiatry 65% of our staff were rated at 3*/4* (internationally excellent/world-leading), which is 6th in the UK. In Hospital-based Clinical Subjects 80% of our staff were rated at 3*/4*, which is 1st overall. We currently attract 76 research grants, worth a combined £37m. The School holds a Silver Athena SWAN award, in recognition of excellence in science, engineering and technology employment in higher education relating to supporting women in science. http://www.ed.ac.uk/schools-department/medicine-vet-medicine/about/medical-schools/biomedical The College of Medicine and Veterinary Medicine The College of Medicine and Veterinary Medicine (http://www.mvm.ed.ac.uk) traces its origins back nearly 500 years (Darwin, Simpson and Conan-Doyle were students here) and is internationally renowned for its research and teaching. Headed by Professor Sir John Savill, the only conjoint Medical and Veterinary Medical School in the UK employs over 2300 academic and support staff within the College and the four Schools; Biomedical Sciences ; Molecular, Genetic and Population Health Sciences; Clinical Sciences and Royal (Dick) School of Veterinary Studies. http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/biomedical http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/molecular-clinical-med http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/clinical-sciences http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/vet-school The undergraduate medicine teaching programme in the College enjoys a very high reputation nationally and internationally, with over 1,300 students enrolled on the MBChB and Intercalated courses and nearly 1000 on the Veterinary Sciences BVS and related programmes. In addition, approximately 2000 students are currently enrolled in the College’s taught and research post-graduate courses, including an extensive range of online distance learning diplomas and degrees. They are trained by over 1000 outstanding academic staff. Details of PhDs, research programmes and studentships are available through our major interdisciplinary research institutes and centres (http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/research/institutes/centres). The academic disciplines within Medicine are largely concentrated in the two teaching hospital campuses in Edinburgh, the New Royal Infirmary at Little France and the Western General Hospital. Both have extensive new infrastructure with major new research institutes and state of the art research facilities on clinical sites. Edinburgh hosts a number of prestigious MRC and BHF Research Centres. The approach is interdisciplinary, with basic and clinical researchers working together at the laboratory bench and in our clinical research facilities to address major themes in basic, clinical and translational medicine. The Royal (Dick) School of Veterinary Science on the new Easter Bush campus houses outstanding teaching and clinical facilities as well as the splendid Roslin Institute, one of the world’s leading veterinary research centres. The College is the UK’s only conjoint medical and veterinary school which affords outstanding opportunities to address ‘One Health’ and Global Health problems of the highest international priority. Research Assessment Exercise (RAE) 2008 In RAE 2008, the College was placed first of 28 submissions in the UK, in Hospital-Based Clinical Subjects. Of all those submitted at the international level 80% of the submission were judged world-leading (4-star, 40%) or internationally excellent (3-star, 40%) levels. The College was placed fourth in Agriculture, Veterinary and Food Science, but was the first-placed veterinary school (by 4*) and delivered the largest volume of 4* research in the whole UK. The College was also sixth in the UK in Psychiatry, Neuroscience and Clinical Psychology, an area further reinforced by the advent of Edinburgh Neuroscience to coalesce the University’s neuroscience activities. The University of Edinburgh For more than four centuries, our people and their achievements have rewritten history time and again. They’ve explored space, revolutionised surgery, published era-defining books, paved the way for life-saving medical breakthroughs and introduced to the world many inventions, discoveries and ideas from penicillin to Dolly the sheep. We have believed that anything is possible. We still do. The latest Research Assessment Exercise highlighted our place at the forefront of international research. This adds to our international reputation for the quality of our teaching and our student experience excellence. As a member of staff you will be part of one of the world's leading universities, with 22 Schools spread over 3 Colleges that offer more than 500 undergraduate and 160 postgraduate courses to over 30,000 students each year. Professional services are critical to this success as well as our world-class teaching, research and student facilities. In fact, we are one of the top employers in Edinburgh, with over 11,700 people spread across a wide range of academic and supporting roles. As a world-changing, world-leading university we are an exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent, develop and reward success and integrate academic, professional and personal career goals, as well as give your career the benefit of a great and distinguished reputation. The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.

Chancellor’s Fellowships

Chancellor’s Fellowships £37,756 - £45,053 College of Humanities and Social Science College of Medicine and Veterinary Medicine College of Science and Engineering The University of Edinburgh, a global top 20 University located in one of the world`s finest cities, continues to invest in the future of its academic staff with the appointment of a cohort of 50 tenure-track Chancellor’s Fellowships across all disciplines. These 5-year Fellowships are intended to support candidates at the start of their independent academic careers. Subject to satisfactory review at the end of year 3, the Fellow will then move to a standard University academic open-ended contract. It is anticipated that most appointees will be successful in obtaining an open ended contract. Our people have been making their mark on the world for more than four centuries. They've explored space, revolutionised surgery, won Nobel Prizes, published era-defining books, paved the way for life-saving medical breakthroughs and laid the foundations for solving the mysteries of the universe. We are looking for highly talented academics who will contribute to our continued achievement of excellence in research. You will already be working in an independent research capacity and will be developing your reputation for high quality research. Chancellor’s Fellows also make an important contribution to enriching student learning experiences through their research, teaching and personal tutoring. You will concentrate on research initially, but will be trained in teaching skills and progressively take up this core academic activity. As we are a global University, we are interested in candidates from any location and we can offer relocation support. The culture of the University is open and diverse and we strive to replicate that in our appointments. Whilst we are proud of our rich heritage, we are a University that looks to the future. We are a global University with world leading interdisciplinary research capability, ideal for collaborative work as required. By joining our research-led community of international academics you will enjoy excellent career opportunities and support. Appointment will normally be made on the Grade 8 Academic scale (£37,756-£45,053), dependent on experience. In exceptional circumstances a more senior appointment may be made. This is an excellent opportunity to be part of one of the world’s top Universities where you will develop your career in a stimulating, friendly and diverse environment that nurtures talent and rewards success. We welcome applications from everyone irrespective of gender or ethnic group. As women and members of ethnic minorities are currently under-represented in posts at this level we particularly encourage applications from members of these groups. For more information visit our website www.ed.ac.uk/schools-departments/human-resources/jobs/chancellors-fellowships which also has full details on how to apply. Closing date: 7 February 2014 (5pm). Committed to Equality and Diversity The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.

Posdoc and PhD studentship

Two position are available in the laboratory of Dr. Alessia Buscaino 1. 1. BBSRC funded Post-doctoral Position (full term-3 years) We are seeking an enthusiastic candidate with a genuine interest in epigenetics and/or fungal pathogens to investigate how heterochromatin domains are assembled and modulated at repetitive DNA sequences. In the lab we are using the fission yeast Schizosaccharomyces pombe as a paradigm to dissect heterochromatin assembly. In parallel, we are investigating how heterochromatic structure affects the biology and pathogenicity of the most common human fungal pathogen: Candida albicans. This study will give important insights into the pathogenicity and virulence of this important fungal pathogen that, in the UK alone, kills 7000 people every year. Dr Buscaino's laboratory is part of the Kent Fungal Group (http://www.kentfungalgroup.com/) and it is located at the University of Kent in the beautiful city of Canterbury. For more information about the project and the research in the lab please send informal enquiries to Dr. Alessia Buscaino at A.Buscaino@kent.ac.uk 2. 2. University of Kent funded PhD studentship A PhD position is available as part of a collaborative project between the laboratories of Dr Alessia Buscaino and Prof David Brown at the University of Kent. Dr Buscaino's lab has funding from the BBSRC and the Royal Society to investigate epigenetic mechanisms regulating assembly and modulation of heterochromatin domains. In this multidisciplinary project, the PhD student will combine fungal genetics, protein biochemistry/biophysics and structural biology to unveil epigenetic mechanisms regulating the yeast to hyphae switch in the fungal pathogen Candida albicans. Both research teams are located at the University of Kent in the beautiful city of Canterbury where we offer a well equipped and vibrant research environment in addition to full training. Please send informal enquiries to Dr. Alessia Buscaino (A.Buscaino@kent.ac.uk). To apply for this position visit: http://www.kent.ac.uk/bio/study/postgraduate/projects/index.html

2 Postdoctoral Research Scientists

Starting Salary from £28,500 to £38,000 (depending on experience). Initial 3 year fixed term contract. Cancer Research UK Beatson Institute in Glasgow is one of Europe's leading cancer research centres. It supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies. These posts are funded through a multi-faceted industrial collaboration investigating the role of RAC and RALGTPases in both CRC and PDAC. They will involve close interaction with team members across multiple sites. Prof Kurt I. Anderson: Imaging GTPase activation in cancer The Tumour Cell Migration Laboratory led by Professor Kurt I. Anderson has pioneered the use of imaging methods (FRAP and FLIM-FRET) to assess pharmacodynamics in vivo (Serrels et al. (2009) Cancer Res 69:2714; Timpson et al. (2011) Cancer Res 71:747; Nobis et al. (2013) Cancer Res 73:4674). We now seek a highly motivated and dedicated postdoctoral researcher to develop the use of FRET probes to read out GTPase activation in pancreatic cancer models. You will use imaging, molecular biology, and biochemical methods to optimize FRET probe performance, followed by use of the optimised probes to characterise mechanistic cancer models in vitro and in vivo. A relevant PhD is required and in depth knowledge of cancer biology and/or imaging would be advantageous. Informal enquiries or applications with covering letter, CV, and names of three referees should be sent to Prof Kurt I. Anderson, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK or by email to k.anderson@beatson.gla.ac.uk Prof Owen Sansom: Testing the functional requirement for RAC and RAL signalling downstream of KRAS mutation in pancreatic and colon cancer KRAS is commonly mutated in both colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). KRAS mutation initiates nearly all PDAC whilst in CRC KRAS mutation occurs after APC mutation to drive progression. Although much work has concentrated on the MAPK and PI3-Kinase signalling pathways downstream of RAS activation, the work of our group (and others) suggest that both RAC and RAL are very important nodes (see Myant et al Cancer Cell 2013). You will use state of the art in vitro and in vivo modelling and imaging as well as established biochemistry and molecular biology. A relevant PhD is required and in depth knowledge of cancer biology and/or in vivo modelling would be advantageous. Informal enquiries or applications with covering letter, CV, and names of three referees should be sent to Prof Owen Sansom, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK or by email to r.gebbie@beatson.gla.ac.uk Closing date for applications: 28th February 2014

postdoctoral call- Spanish MINECO Postdoctoral Program

We are seeking postdoctoral candidates interested in joining our research group under the Spanish MINECO Postdoctoral Program. Specific Information about this postdoctoral call can be found at Spanish BOE of Dec 31 2013 (page 107239). Eligibility criteria include: 1. Ph.D. degree at the moment of contract (summer 2014) 2. Ph.D. thesis defended later than Sept 1, 2009. 3. Ph.D. carried out outside the Universidade de Santiago de Compostela, Spain. 4. Experience in techniques used in our lab (see below) 5. Publication record. We are looking for highly motivated people, with a background in Molecular Biology, Genetics or Biochemistry. Experience with mouse models or cell cycle research is a plus. Our current area of interest is to study the biology of cell cycle inhibitors, and in particular their in vivo functions on and beyond cell cycle regulation. Our work is based on cellular and molecular biology, biochemistry, genomics and animal models. Further information on our group is available at http://www.usc.es/cimus/en/research/research-groups/cell-cycle-and-oncology-group-ciclon Please send your CV, letter of motivation (up to one page) and the names of 2 references via email to anxo.vidal@usc.es The deadline for this application is February 10, 2014.

Postdoctoral position on Telomeres

A Postdoctoral position is available in the laboratory of Miguel Godinho Ferreira to study DNA damage responses at telomeres in fission yeast. The laboratory is located at Instituto Gulbenkian de Ciência near Lisbon, Portugal. We are looking for a highly motivated scientist with a strong background in molecular biology and DNA damage responses willing to work in multidisciplinary environment that encompasses molecules, organism and disease. We are funded by Howard Hughes Medical Institute (USA) and the Foundation for Science and Technology (Portugal). Based on previous work from our group (Carneiro et al. Nature 2010), we are unravelling the mechanisms preventing the recognition of telomeres as DNA double-strand breaks. We propose that epigenetic environment at telomeres represents the hallmark of chromosome ends that distinguishes them from deleterious DNA lesions. To gain insights into the existence of such “chromatin privileged regions”, we are studying histone modifications both on nuclease induced DSBs and telomeres. The Instituto Gulbenkian de Ciência (http://www.igc.pt) is the Portuguese flagship of biomedical research. English is the main language in the campus (all seminars and communications are in English) and we have a significant foreign scientific community (ca. 30% from 34 countries). The Institute is privately supported by the Gulbenkian Foundation to carry biomedical research and education. The IGC offers excellent facilities and services to foreign and Portuguese research groups, in particular to young post-doctoral fellows. Attesting this, TheScientist/F1000 awarded us with the title Best Place to Work for postdocs in 2010 and 2011. Candidates are encouraged to send a cover letter, Curriculum vitae and two reference letters to Miguel Godinho Ferreira by email (mgferreira@igc.gulbenkian.pt) under the subject: “Postdoctoral position” by 28th February. For more information, please visit our web site: http://sites.igc.gulbenkian.pt/telomere/

Position available for application to the Spanish MINECO Postdoctoral Programme

Centro Nacional de Investigaciones Cardiovasculares Department of Epidemiology, Atherothrombosis and Imaging Position available for application to the Spanish MINECO Postdoctoral Programme (2+2 years, BOE 313, December 31, 2013, page 107239) Eligibility criteria: • Doctoral thesis defended not before September 1, 2009 (but see exceptions in BOE), and predoctoral training not in CNIC • PhD degree must be hold at a date before of or coinciding with the publication of MINECO’s decision (possibly in June 2014) • Candidates cannot be recipients of Ramón y Cajal or Juan de la Cierva contracts from previous years, and cannot apply to the Ramón y Cajal Program this year. Moreover, they can only apply for 1 research center • Particularly valued will be experience in molecular/cellular biology and in animal models of cardiovascular disease and/or aging, as well as first author publications in international peer-reviewed journals The project will be carried out in the Molecular and Genetic Cardiovascular Pathophysiology Laboratory (Dr. Vicente Andrés, http://www.cnic.es/en/imagen/fisiopatologia/index.php). We investigate the mechanisms that underlie atherosclerosis and vascular calcification and how aging contributes to these anomalies. We are particularly interested in the role of A-type lamins (lamin A/C) on cardiovascular disease and aging, including Hutchinson-Gilford progeria syndrome (HGPS), a premature aging disease that recapitulates key aspects of physiological aging. Our experimental strategy involves a multifaceted approach that combines in vitro, cellular, animal and human studies and a variety of technologies including mouse genetic engineering, proteomics, transcriptomics, FRET, intravital microscopy, non-invasive imaging, confocal microscopy, etc. Selected publications of the group: •Chèvre, R. et al. Circ Res (in press) •Villa-Bellosta, R. et al. Circulation. 2013 •Trigueros-Motos, L. et al. Arterioscl Thromb Vasc Biol. 2013 •Rivera-Torres, J. et al. J Proteom. 2013 •Fuster, JJ. et al. Arterioscl Thromb Vasc Biol. 2011 •González, JM et al. J Cell Biol. 2009 •Ivorra, C. et al. Genes & Dev. 2006

candidates for a two years postdoc contract

We look for candidates for a two years postdoc contract (“Contratos para la formación posdoctoral ” BOE. December 31st 2013. Deadline March 3rd 2014 ). The work will be in the group of “Extracellular Matrix Remodeling in the Cardiovascular System” at the Centro de Biología Molecular Severo Ochoa, Madrid, Spain. The formation and assembly of extracellular matrix componentes is a fundamental process to maintain the integrity of the connective tissue, and therefore, extracellular matrix alterations are associated with some diseases, including Marfan or Ehlers‐Danlos Syndromes, as well as with fibrotic disorders including idiopathic pulmonary fibrosis, liver cirhosis, systemic sclerosis, etc. By using in vivo and in vitro approaches, we study the molecular mechanisms governing the development of extracellular matrix‐related disorders and explore new therapeutic approaches for the clinical treatment. Recent publications: 􀂙Busnadiego, O., González‐Santamaría, J., Lagares, D., Guinea‐Viniegra, J., Pichol‐Thievent, C., Muller, L. and Rodríguez‐Pascual, F. 2013. LOXL4 is induces by TGF‐β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling. Molecular and Cellular Biology, 33: 2388‐2401. 􀂙Lagares D, Busnadiego O, García‐Fernández RA, Kapoor M, Liu S, Carter DE, Abraham D, Shi‐Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM, Leask A, Lamas S, Rodríguez‐Pascual F. 2012. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis & Rheumatism, 64: 1653‐1664. 􀂙Lagares D, García‐Fernández RA, Jiménez CL, Magán‐Marchal N, Busnadiego O, Lamas S, Rodríguez‐Pascual F. 2010. Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. Arthritis & Rheumatism, 62: 878‐889. Please contact with: Fernando Rodríguez Pascual Email: frodriguez@cbm.csic.es Tel. +34 911964505 Web: http://web4.cbm.uam.es/joomla‐rl/index.php/en/scientific‐departments/cell‐biologyand‐ immunology?id=%20523 Analysis of the subcellular localization of the isoform 4 of lysyl oxidase (LOXL4) fused to greeen fluorescent protein in aortic endothelial cells. Colocalization with the endoplasmic reticulum marker (confocal microscopy). LOXL4-GFP ER marker: CALNEXIN

PhD student vacancy

VIB - Ghent University – Ghent – Belgium Inflammation Research Center Rudi Beyaert lab - Unit of Molecular Signal Transduction in Inflammation http://www.vib.be/Rudi-Beyaert In the context of the VIB International PhD Program in Life Sciences we are looking for a PhD student to work on the following topic: “Deciphering the ubiquitin code by advanced live-cell imaging of protein ubiquitination in human and plant cells”. This project aims to create a novel cutting-edge research tool for the ubiquitin community and to discover new general paradigms for the role of protein ubiquitination in both humans and plants. The work will be performed in close collaboration with the group of Prof. Alain Goossens of the VIB Plant Systems Biology Department and with the VIB Bio Imaging Core facility. Interested candidates are refered to http://www.vib.be/phd (see project 5) for more details, admission requirements and details to apply in the context of the VIB International PhD Program. Deadline for application is February 15, 2014. The selected candidates will be fully funded for a 4 year period with a yearly net salary of 25.000 €. Selected candidates are expected to start with their Ph.D. around the opening of the academic year in October 2014. More information can be obtained from Rudi.Beyaert@irc.vib-ugent.be

OFERTA DE CONTRATO POSTDOCTORAL MINECO

SE BUSCA INVESTIGADOR/A POSTDOCTORAL INTERESADO/A EN SOLICITAR UN CONTRATO PARA LA FORMACIÓN POSTDOCTORAL (BOE 31/12/2013). LLEVARÍA A CABO UN PROYECTO RELACIONADO CON LA TETRAPLOIDÍA NEURONAL EN EL CEREBRO NORMAL Y PATOLÓGICO. PERFIL: DOCTORADO OBTENIDO DESPUÉS DEL 1 DE SEPTIEMBRE DE 2009. Experiencia en BIOLOGÍA CELULAR, BIOQUÍMICA y BIOLOGÍA MOLECULAR. El conocimiento de mecanismos de regulación epigenética será valorado positivamente. IMPRESCINDIBLE TENER VARIAS PUBLICACIONES COMO PRIMER AUTOR (DE IMPACTO MEDIO-ALTO). Publicaciones más relevantes del grupo en esta línea de investigación: Morillo SM, Escoll P, de la Hera A y Frade JM Morillo SM, Abanto E, Román MJ y (2010) Somatic Tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc. Natl. Acad. Sci. USA 107:109-114. Frade JM López-Sánchez N y (2012) NGF-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. Mol. Cell. Biol. 32: 2722-2737. Frade JM (2013) Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. J. Neurosci. 33:7488-7500. Los interesados deben enviar el CV antes del 10 de febrero de 2014 Instituto Cajal, CSIC a: frade@cajal.csic.es José María Frade López Avda Doctor Arce, 37 28002 Madrid (SPAIN) Tel.: 91 585 4740 Web: http://www.cajal.csic.es/departamentos/frade-lopez/frade-lopez.html

PhD Studentship

Funding and Finance BBSRC DTP MRes/PhD Studentship - Understanding Microtubule Dependent Signalling in the Generation of Cellular Asymmetries Reference Code: CB106 Details: Name of the supervisors Dr J Rodriguez, Institute for Cell and Molecular Biosciences (ICAMB) Dr E Veal, Institute for Cell and Molecular Biosciences (ICAMB) Sponsor This studentship is sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC) as part of the Doctoral Training Partnership (DTP) Duration of the award Four years (MRes Biosciences followed by a three-year PhD) Project description The aim of this project is to understand the microtubule (MT) dependent mechanisms that regulate cell polarity and their implications for complex processes such as ageing. By breaking symmetry, cells are able to generate diversity, migrate, and organise themselves into more complex structures. In such cell polarity processes, MTs often act as an internal source of asymmetry leading to acto-myosin reorganisations and asymmetric distribution of polarity effectors (PAR proteins). Polarity maintenance is crucial for tissue homeostasis and when lost it can lead to cancer. In addition, accumulating evidence suggests that loss of polarity could be a hallmark of cellular ageing. In previous research we have generated a comprehensive polarity genetic network, identifying candidate genes and signalling pathways important for cell polarity (NatCellBiol.2012 vol.15(1) pp.103-12). Exploiting this network the student will identify proteins involved in the MT dependent mechanisms that regulate C.elegans asymmetric first cell division. This cell division has proved an excellent model for identifying key conserved polarity regulators and understanding cell polarity mechanisms. To characterize the candidate genes we will perform loss of function analysis by RNAi in combination with live imaging and immunofluorescence staining of polarity and MT markers. Genetic screens will be carried out to determine the signalling pathways involved and to analyse their possible relationship to lifespan regulatory genes. The supervisory team’s expertise in C. elegans (JR,EV), cell polarity (JR) and ageing (EV) will provide a comprehensive research environment that will support the scientific growth of the student and his training in state-of-the-art molecular and cell biology techniques. Value of the award and eligibility Depending on how you meet the BBSRC’s eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,726 (2013/14). A partial award covers fees at the UK/EU rate only. Person specification Candidates should have or expect to achieve a first-class or upper-second-class Honours degree in a relevant science subject. Students interested in developmental biology, cell polarity and in cell biology/microscopy techniques are encouraged to apply. How to apply You must apply through the University’s online postgraduate application form selecting ‘Master of Research/Doctor of Philosophy (Medical Sciences) – Cell and Molecular Biosciences ' as the programme of study. Please insert the studentship/partnership reference number CB106. Only mandatory fields need to be completed (no personal statement required) but you must attach a copy of your CV and a covering letter, quoting the title of the studentship and reference number CB106. Closing date for applications The post will remain open until a suitable applicant is appointed. Early application is advised. Further information For further details, please contact: Dr J Rodriguez E-mail: jr417@cam.ac.uk Telephone:+44 (0) 1223 767 224

OFERTA DE CONTRATO POSTDOCTORAL. CONVOCATORIA MINECO

Doctor en el área de la Biomedicina (Bioquímica, Biología, Farmacia,…) con fecha de lectura de tesis 2009 o posterior (incluyendo fecha de lectura hasta Junio 2014) Se ofrece: La posibilidad de solicitar una de las Ayudas contratos para la formación posdoctoral de la convocatoria del Ministerio de Economía y Competitividad (B.O.E de 31 de Diciembre de 2013 Pag 107239) para la realización de un trabajo postdoctoral en el Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM en el laboratorio de la Dra. Pilar Santisteban en el campo de estudio de los mecanismos moleculares que controlan la diferenciación celular durante los procesos de transformación y metástasis de la glándula tiroidea. Se requiere: Ser primer autor de varias publicaciones científicas en revistas de buen impacto en el campo de la Biomedicina. Interesados enviar CV antes del 10 de febrero a: Dra. Pilar Santisteban. Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM Email: psantisteban@iib.uam.es Tel: 91 585 4455 Ver detalles de la actividad científica del grupo y publicaciones en: www.iib.uam.es Varias Publicaciones últimos años sobre la temática del trabajo a realizar: Fernández et al (2013) PLoS ONE. 8(5) e62849. Landa et al (2013) PLoS One , 8 (9) e74765 Xing et al (2013) JAMA 309: 1492-1501 Zaballos and Santisteban (2013) Mol. Endocrinol. 27: 50-62 Ruiz-Llorente et al (2012) BMC Genomics. 13: 147 Leoni et al (2011) Mol Endocrinol 25: 1924-1935 Riesco-Eizaguirre et al (2011), J Clinical Endocrinology & Metabolism 96: E1435-1443 Riesco-Eizaguirre et al (2009), Cancer Research, 69: 8317-8325 Landa et al. (2009) PLoS Genet. 5 (9):e1000637 (2009)

Postdoctoral research position

Postdoctoral research position in the area of telomeres, aging and DNA repair at the University of North Carolina at Chapel Hill. Position open for in vitro studies of DNA-protein interactions central to telomere maintenance, the control of aging, and DNA repair. Emphasis on protein purification, biophysical studies including electron microscopy, collaborations with US/international groups. Applicant must have a Ph.D. degree and strong background in biochemistry and ideally previous experience in DNA-protein interactions. Work may entail some cryoEM. The Lineberger Comprehensive Cancer Center provides a strong postdoctoral training environment and the University of North Carolina is an equal opportunity employer. Laboratory of Dr. Jack Griffith. Submit c.v. to jdg@med.unc.edu.

PhD Studentship (fully funded)

Institution: University of Sussex Dept/School/Faculty: School of Life Sciences PhD Supervisor: Dr Claudio Alonso Application Deadline: Saturday, February 1, 2014 Funding Availability: 3.5-year PhD Salary (European/UK Students Only) Start Sept 2014 A PhD position is available in the group of Dr. Claudio Alonso http://www.sussex.ac.uk/lifesci/alonsolab/ at the John Maynard Smith Building of the School of Life Sciences in the University of Sussex at Brighton (UK) to work in the area of Molecular, Cell and Developmental Biology. The project will investigate the impact of various RNA regulatory processes on Hox gene expression and function during Drosophila and mammalian neural differentiation and will apply a wide spectrum of novel experimental techniques in RNA Molecular Biology, Genetics, Cell and Developmental Neurobiology and state-of-the-art Imaging and Microscopy methods. The work will be part of an ambitious long-term research program funded by a Wellcome Trust Investigator Award recently made to Dr. Claudio Alonso http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/Investigator-Awards/ index.htm and will be co-supervised by Prof. Guy Richardson, FRS, the head of the Neuroscience section at the School of Life Sciences at Sussex. The successful candidate will be an outstanding, committed and highly motivated graduate student seeking to develop an original project within the broad area of Molecular and Developmental Neuroscience. Applicants should have (at least) a 2.1 degree classification (or equivalent) in Biology, Biochemistry, Neuroscience or a related discipline. The University of Sussex is located 10-min away from the lively and cosmopolitan seaside city of Brighton on the UK South Coast, 60-min away from central London, 30-min away from London Gatwick Airport and with full access to the beautiful country side of the Sussex South Downs. Closing date for applications: 01 February 2014 For full details and how to apply see: http://www.findaphd.com/search/ProjectDetails.aspx?PJID=49246 For informal enquiries please contact Claudio Alonso at c.alonso@sussex.ac.uk The University of Sussex is committed to equality of opportunity

Postdoctoral Position

We are searching for candidates to apply for a two-year Postdoctoral Position funded by MINECO (Spain) (BOE 31-12-2013 ) to work on our Research Project “The meiotic recombination checkpoint: epigenetic regulation” (BFU2012-35748). Our group is interested in the molecular mechanisms involved in the maintenance of genomic stability. We study the meiotic cell cycle checkpoints that ensure proper chromosome segregation and avoid the formation of aneuploid gametes. We make special emphasis on the role of certain chromatin modifications. Salary: 21,500 euros/year. Candidates must have obtained the PhD after September 1st, 2009 Interested candidates please contact as soon as possible (before February 5) with: Dr. Pedro A. San-Segundo Instituto de Biología Funcional y Genómica CSIC-USAL E-mail: pedross@usal.es Phone: 923294902 http://ibfg.es/en/pedro-san-segundo-en

Postdoctoral positions to study the mechanisms and regulation of chromosome replication in eukaryotic cells

Applications are invited for Postdoctoral Researchers to work in the laboratory of Karim Labib, to study the mechanisms of action of the eukaryotic replisome, and its regulation by ubiquitylation and phosphorylation. We want to understand how the replisome allows eukaryotic cells to preserve the genetic and epigenetic information within their chromosomes. These issues are critical for the survival of all eukaryotes, and in humans are intimately linked to the development and treatment of cancer. The eukaryotic replisome is much more complex than its bacterial counterpart, presumably reflecting additional functions and more complex regulation. We aim to study how the replisome contributes to the preservation of parental chromatin, and will explore how the unique leading and lagging strand machineries contribute to replisome function. In addition, we are developing new in vitro and in vivo systems with which to study how the replicative DNA helicase is regulated by ubiquitylation and phosphorylation. It seems likely that the underlying mechanisms and regulation have been highly conserved during evolution, and progress in this area could ultimately be exploited to devise improved strategies for treating human diseases such as cancer. The successful applicants will use a state-of-the-art blend of biochemistry and genetics. The MRC Protein Phosphorylation and Ubiquitylation Unit, and the College of Life Sciences, together provide a fantastic environment for studying genome integrity and its regulation by post-translational modifications, with many other research groups that have complementary interests to our own. There will also be strong opportunities for interactions with the six major Pharmaceutical companies that support the Division of Signal Transduction Therapy (DSTT see http://www.ppu.mrc.ac.uk/overview/DSTT.php), which aims to accelerate the exploitation of any discoveries made within the unit. The positions are available for 3 years. For informal enquiries please contact Karim Labib (kpmlabib@dundee.ac.uk). For further details on the research of Karim Labib’s laboratory (http://www.ppu.mrc.ac.uk/research/?pid=1012) and publications (http://www.ppu.mrc.ac.uk/research/?pid=1012&sub1=publications) please peruse the indicated website links.