Se busca candidato para beca de doctorado FPI-UAM en INSTITUTO DE INVESTIGACIONES BIOMEDICAS ALBERTO SOLS

 We are currently looking for candidates to apply for a FPI-UAM 
 fellowship. Candidate requirements:
 -Bachelor degree in Biomedical Sciences (Biology, Biotechnology, 
 Medicine, Pharmacy, Veterinary), last three academic years, with an 
 average mark of at least 2.5/4.
 A Master in Biomedical Sciences must be at least in progress.
 Lenguage requirements: English
 Applications: send your CV, academic resumee and brief statement of 
 your research interest, as well as the contact information of at least 
 one referee that would provide recomendation letters to: 
 *mpmonsalve@iib.uam.es

 Obesity has been shown to be an independent rirk factor in an ever 
 increasing numer of major human pathologies. These include 
 cardiovascular disease, neurodegenerative diseases, and and cancer, to 
 cite some of the most prevalent ones. Less widely aknowleded but also 
 relevant are inmune system disfuncitons including autonimune diseases, 
 alergy, and poor response to infections, graft rejection/failure and 
 loss of stem cell regenerative capacity. To understand the molecular 
 basis of the obesity related increased risk in such a disparate set of 
 human pathologies seems an apalling task. Nevertheless, an important 
 number of studies has succesfully addressed this question. Currently, 
 the best accepted model points to the link that joins the metabolic 
 pathways with those that control basic cellular processes like 
 proliferation, migration, differentiation and the cell capacity to 
 respond to different types of insults (stressors). Along these lines 
 it is worth mentioning that a pletora of recent studies has shown that 
 cells with an active oxidative metabolism are much more resistant to 
 stress than glycolytic cells. The protein responsible for this major 
 "metabolic switch" in mammals is PGC-1?. The transcriptional 
 coactivator PGC-1? orchestrates the cellular response to changes in 
 nutrient availability, exercise, temperature, etc. Because of these 
 characteristics PGC-1? has got the epithet of "Master metabolic 
 regulator".
 Our aim is to understand the pathways that link metabolic dysfunction 
 to human pathologies and to develop new therapeutical strategies.