CONTRATO POSTDOCTORAL UNIVERSIDAD DE OVIEDO

Se ofrece un contrato postdoctoral para trabajar en el Departamento de Biología Funcional (Área Microbiología) de la Universidad de Oviedo en ingeniería genética de la biosíntesis de compuestos antitumorales en actinomicetos bajo la dirección de los Drs. José Antonio Salas Fernández y Carmen Méndez Fernández. Las personas interesadas deberán estar en posesión del título de Doctor en áreas relacionadas con las Ciencias de la Vida o de la Salud. Se valorará positivamente la experiencia en trabajo con microorganismos y especialmente en biología molecular de microorganismos. Los interesados deberán enviar su “curriculum vitae” así como el nombre de dos personas que puedan emitir una referencia antes del 25 de Noviembre a la dirección de correo electrónico jasalas@uniovi.es. La fecha de incorporación sería entre Enero y Febrero 2014.

Postdoctoral Associate Position in Glycomics Analysis of Glycoproteins

*Imperial College London* -Department of Life Sciences *Faculty of Natural Sciences* *Salary scale: £32,750 - £41,540 per annum* Applications are invited for a Research Associate position to work in the research group of Professor Anne Dell FRS and Dr Stuart Haslam. The project is part of a major BBSRC-funded core grant which supports collaborative glycobiology research. You will be joining a dynamic, international, multidisciplinary research group located within the South Kensington Campus. The successful candidate will be responsible for informatics components of the research programme including the development of tools for the rapid, automatic interpretation of mass spectra and their incorporation into data bases. You must have a PhD or equivalent in a biological or computer science. Experience in biopolymer mass spectrometric analysis, glycobiology or bioinformatics are essential. You must also have experience in laboratory research or bioinformatics as evidenced through publications in peer reviewed journals and evidence of original research and achievements. You must have excellent verbal and written communication skills, be able to develop and apply new concepts and write clearly and succinctly for publication. You must also be able to work and collaborate within multidisciplinary research team, and have the ability to present results clearly and concisely in both written and spoken form. A high analytical capability and the ability to develop and apply new concepts are also essential. You must be able organise own work with minimal supervision and prioritise your work in response to deadlines. The ability to lead research projects in new directions, direct the work of a small research team, and motivate others to produce a high standard of work would be advantageous. This appointment is available for three years and will start as soon as possible. For initial enquiries, please contact Dr Stuart Haslam at s.haslam@imperial.ac.uk Our preferred method of application is online via our website http://www3.imperial.ac.uk/employment (please select "Job Search" then enter the job title or vacancy reference -- *NS 2013 231 IL* - number including spaces into "Keywords"). Please complete and upload an application form as directed. Alternatively, if you are unable to apply online, please contact Dr Louise English atbioinformatics@imperial.ac.uk , to request an application form. *Closing date: 24 November 2013 (Midnight GMT)* /Committed to equality and valuing diversity. We are also an Athena Bronze SWAN Award winner, a Stonewall Diversity Champion and a Two Ticks Employer./

Marie Curie Initial Training Programme PhD & Postdoc Positions Available

Training In Neurodegeneration, Therapeutics Intervention and Neurorepair (TINTIN) TINTIN is a pan-European, multi-disciplinary project aimed at training 12 PhD students in neuroscience research, with an emphasis on the basis of neurodegeneration, neurotherapeutics development and neurorepair. The project is funded under the EU Framework 7. PhD training fellowships are now available commencing on January 2014. Successful applicants will undertake advanced research training projects on metabolism and autophagy in neurons, induced pluripotent stem cells and neurorepair systems. Parallel research projects will involve computational modelling of metabolism in the dopamine neuron and the in silico design of novel therapeutics that are selectively transported into the dopamine neuron. This fundamental training and research will be merged with new cutting edge glycan based biomarker technologies, drug simulation and computational/mathematical models of dopaminergic neurons. Each PhD candidate will be seconded for 3–5 month period to a European industrial partner appropriate to their research project, to obtain training in leading-edge technologies. Candidates will also be provided with training in aspects of project management and commercial innovation. Positions for 2 postdoctoral research fellows (experienced researchers with less than 10 years experience) are also available. Essential/Desirable Criteria All candidates should possess a keen interest in neuroscience and in the underlying basis of neurological conditions, such as Parkinson’s disease, depression, addiction and ADHD. Prospective PhD candidates should hold a BSc/MSc degree, or equivalent, in physics, chemistry, pharmacy or the biological sciences. How to apply Applicants should include a covering letter, which should specify their reasons for applying, and suitability as a candidate, along with a CV and names and contact details (email addresses) of two referees. Initial enquiries and formal applications should be sent to the relevant group leaders. TINTIN is a mobility-based EU program and researchers are required to move to a country to commence their PhD training project. Deadline for applications The final date for applications is 20 November 2013. Early Stage Researcher PhD projects available: ESR1: Regulation of the antioxidant response of dysfunctional dopaminergic neurons Host: Universidad de Salamanca Supervisor: J. Bolanos (jbolanos@usal.es) Duration: 36 months ESR2: Characterisation of the bioenergetic and redox status of dopaminergic neurons in transgenic mice Host: Universidad de Salamanca Supervisor: J. Bolanos (jbolanos@usal.es) Duration: 36 months ESR3: The effect of glutathione on mitochondrial dynamics & function in the dopamine neuron Host: Trinity College Dublin Supervisor: G. Davey (gdavey@tcd.ie) Duration: 36 months ESR4: How does the cytochrome P450 system control drug metabolism in the dopamine neuron? Host: University of Siena Supervisor: M. Valoti (massimo.valoti@unisi.it) Duration: 36 months ESR5: Crosstalk between mitochondrial & lysosomal dysfunction in the dopamine neuron Host: Trinity College Dublin Supervisor: G. Davey (gdavey@tcd.ie) Duration: 36 months ESR6: How does glucocerebrosidase control autophagy in the dopamine neuron? Host: University College London Supervisor: S. Heales (Simon.Heales@gosh.nhs.uk) Duration: 36 months ESR7: Using human wild type and parkinsonian iPS cell lines as a model for neurodegeneration to investigate mechanisms of cell signalling that control mitochondrial turnover Host: Trinity College Dublin Supervisor: J. Murray (james.murray@tcd.ie), G. Davey (gdavey@tcd.ie) Duration: 36 months ESR8: Neurotoxin models of Parkinson’s disease & characterisation of the dopamine transporter internalisation process in patient-specific dopamine neurons. Host: University of Heidelberg Supervisor: P. Schloss (patrick.schloss@zi-mannheim.de) Duration: 36 months ESR9: In silico reconstruction of the dopamine transporter and design of new drugs with neuroprotective properties Host: Kadir Has University Supervisor: K. Yelekçi (yelekci@khas.edu.tr) Duration: 36 months ESR10: Development of new drugs to inhibit the neurodegenerative process in dopamine neuron Host: University of Siena Supervisor: M. Valoti (massimo.valoti@unisi.it) Duration: 36 months ESR11: Characterisation of the cell surface glycome on the dopamine neuron Host: University of Manchester Supervisor: S. Flitsch (sabine.flitsch@manchester.ac.uk) Duration: 36 months ESR12: Glycans, glycolipids and gangliosides related to dopaminergic cell death Host: The National Institute for Bioprocessing Research and Training Supervisor: P. Rudd (pauline.rudd@nibrt.ie), J. Bones, (jonathan.bones@nibrt.ie), G. Davey (gdavey@tcd.ie) Duration: 36 months Experienced Researcher Projects Available: ER1: The mechanisms that control mitochondrial dynamics & function in the dopamine neuron. Host: Trinity College Dublin Supervisor: G. Davey (gdavey@tcd.ie) ER2: What mechanisms control autophagy in the dopamine neuron? Host: University College London Supervisor: S. Heales (Simon.Heales@gosh.nhs.uk) Additional Requirements ENGLISH Proficiency: Excellent It is a requirement that network fellows will show that their ability to understand and express themselves in both written and spoken English is sufficiently high for them to derive the full benefit from the network training. Early-stage researchers (ESR) are those who are, at the time of selection by the host, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged. Experienced researchers (ER) are defined as researchers who, at the time of recruitment by the beneficiary, are: 1) in possession of a doctoral degree, independently of the time taken to acquire it, or have at least four years of full-time equivalent research experience, and 2) have less than five years of full-time equivalent research experience. Conditions of international mobility of researchers: researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of selection by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.

SE BUSCA CANDIDATO/A PARA REALIZACION DE TESIS DOCTORAL EN BIOMEDICINA

Grupo de Investigación: El candidato/a se incorporaría al Diabetes Research Group en el Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)/Facultad de Medicina UAM, dirigido por el Prof. Jesús Egido de los Ríos. Proyecto: Identificación de mediadores y rutas implicadas en los mecanismos de daño renal y vascular en Diabetes. Búsqueda de dianas terapéuticas. Financiación: Se solicitaran ayudas predoctorales en convocatoria inmediata. Requisitos: Licenciatura reciente en Bioquímica, Biología, Farmacia o Químicas Se valorará: 1. Expediente académico competitivo (mayor de 2) 2. Experiencia previa en laboratorios de Investigación (se valoraran conocimiento de cromatografía y/o espectrometría de masas). 3. Capacidad de trabajo y de aprendizaje, y una alta motivación científica. 4. Conocimiento del inglés. Los interesados deberán dirigirse a: sebastian.mas@uam.es

Post-Doctoral Researcher in microRNAs and Neuroscience, Dublin, Ireland

The Centre for the Study of Neurological Disorders at the Royal College 
of Surgeons in Ireland (Dublin, Ireland) is seeking an excellent 
Post-Doctoral Researcher to carry out studies on the role of microRNAs 
in epilepsy. The project will involve identification and functional 
studies on microRNAs and their targets within the brain in experimental 
models and human tissue. Applicants should have a background in 
neuroscience or equivalent discipline, and strong skills with 
human/mouse genetics, biochemistry, molecular biology, cell biology and 
bioinformatics.

Recent publications by the group: Jimenez-Mateos et al. (2012) Nat Med 
18(7):1087-94;

Appointment: The post is available immediately for up to three years. 
Salary is based on experience. Interested candidates are invited to 
submit their CV along with a brief cover letter and names of two 
referees to dhenshall@rcsi.ie or evajimenez@rcsi.ie.

Postdoctoral positions

Postdoctoral positions are available starting January 2014 in the Cell 
Growth and Division laboratory at the European Institute of Chemistry 
and Biology (IECB), Bordeaux, France. The team use interdisciplinary 
techniques including state-of-the-art imaging, modeling and biochemistry 
to understand how cell growth is coordinated with cell cycle 
progression, a central problem in cell biology (McCusker & Kellogg Curr. 
Opin. Cell Biol. 2012). The team recently uncovered a novel mechanism by 
which a robust polarity axis is established during the cell cycle (Jose 
et al. J. Cell Biol. 2013). The projects will explore how membrane 
trafficking dynamics and Rho GTPase activity are modulated during the 
cell cycle (McCusker et al. Nat. Cell Biol. 2007; McCusker et al. Mol. 
Biol. Cell 2012). Since one project will involve high spatial and 
temporal resolution imaging, experience in biophysics and/or cell 
biology would be ideal. The second project will involve the biochemical 
investigation of Rho GTPase regulation, requiring expertise in 
biochemistry; however, the demonstration of other relevant skills will 
be welcomed.

IECB is a dynamic research institute housing 16 teams with expertise in 
the field of membrane/lipid biology, cell biology and chemistry, with 
which the candidate will have the opportunity to interact. The Cell 
Growth and Division laboratory has access to the technology platforms 
available at the University of Bordeaux, including cutting-edge imaging 
facilities.

Candidates interested in applying for the position should send a short 
cover letter outlining their research interests and a cv to the email 
address below. Candidates should also arrange for two letters of 
recommendation to be sent to Dr. Derek McCusker: 
growthanddivision2013@gmail.com

See also: 
http://www.iecb.u-bordeaux.fr/teams/MCCUSKER/McCuskerlab/Welcome.html

CONTRATO DE AYUDANTE DE INVESTIGACIÓN

Laboratorio de Bioquímica Estructural y Computacional, Universidad Católica de Valencia Asociado al Proyecto Nacional

MEC BFU2012- 30770

 

Proyecto de investigación.

El ARN desempeña un papel central en el funcionamiento de los organismos vivos y muchas moléculas de ARN humanas, bacterianas y virales poseen un

potencial terapéutico considerable. Sin embargo, relativamente pocos fármacos que unen ARN han tenido impacto clínico hasta el momento. Además de agentes

antisentido o interferentes, para abordar este tipo de dianas también es posible utilizar pequeñas moléculas orgánicas que reconozcan específicamente las cavidades formadas por estructuras terciarias de ARN e interfieran con su función. Para ello es imperativo identificar nuevos esqueletos químicos que superen las dificultades asociadas al reconocimiento de

esta biomolécula.

 

El ayudante de investigación se verá involucrado en el diseño de fármacos que interaccionen con estructuras de ARN del virus de la hepatitis C y del virus de la

inmunodeficiencia humana tipo 1 . Para ello empleará una combinación de

métodos bioquímicos, biofísicos (RMN, fluorescencia, SPR y otros) y computacionales, en colaboración con grupos de química orgánica y virología.

 

Supervisor: José Gallego (www.researchgate.net).

 

Publicaciones seleccionadas:

González-Bulnes L.; Ibáñez I.; Catalán S.; Alcamí J.; Fustero S.; Gallego J. Nuevas moléculas para el

tratamiento de la infección por el virus de la inmunodeficiencia humana tipo 1 y otras enfermedades.

Solicitud de patente P201330235 (2013).

 

González-Bulnes L.; Ibáñez I.; Bedoya, L.M.; Beltrán, M.; Catalán S.; Alcamí J.; Fustero S.; Gallego J.

Structure-based design of a new RNA-binding scaffold that inhibits HIV

-1 RRE- Rev ribonucleoprotein function. Enviado.

 

Lugar de trabajo: Facultad de Medicina, Universidad Católica de Valencia. C/Quevedo 2, 46 001 Valencia. www.ucv.es.

 

Condiciones: Contrato de 18 MESES, con fecha de comienzo 1 de Enero de 2014 y retribución de €14935 brutos anuales.

 

Requisitos: Licenciados o Doctores en Bioquímica, Química, Biotecnología, Farmacia o Biología. Los licenciados deberán poseer un título oficial de Master, y se valorará positivamente el interés en realizar una tesisdoctoral.

 

Solicitud: los candidatos deberán enviar su CV, certifica dos académicos de Licenciatura y Master o Doctorado que incluyan la nota media obtenida, y al menos una carta de recomendación a José Gallego

(jose.gallego@ucv.es).

 

Fecha límite de envío de solicitudes: 8 Noviembre 2013

 

Posición como Investigador Asociado C/Investigador Titular A (Genómica Funcional de Plantas) en el Centro de Ciencias Genómicas.