Postdoctoral position in Paris

A three year postdoctoral position is available immediately in the team of Sophie Saunier (PhD,) “Pathophysiology of nephronophthisis and renal hypodysplasia” at Imagine Institute, Hôpital Necker-Enfants Malades, Paris Descartes University, Paris, France.
Mission The successful applicant will work within an internationally recognized group actively involved in clinical, genetic and functional studies on nephronophthisis (NPH) and renal multicystic hypodysplasia (RHD), two major hereditary causes of end stage renal failure in children which can be associated with extrarenal phenotypes (ciliopathies). Our work widely contributed to identify many of the responsible genes (NPHP) and to show that nephronophthisis is a "ciliopathy". Indeed, the products of most of these genes are localized and play key and highly conserved functions at the primary cilium. We also showed that NPHP proteins play an important role in epithelial morphogenesis through their interaction with key actors of the junctions and by controlling the Wnt/PCP pathway. Our goals are to identify novel NPH and RHD genes by high throughput sequencing approaches and to characterize their cellular functions (cilia/junctions) and their role in key signaling pathways controling kidney development and epitheliogenesis through the use of invalidated in vitro (kidney cell lines) and in vivo (mice and zebrafish) models. The proposed project will be more particularly focused on the study of signaling pathways controlled by the newly identified gene products using the above described in vivo and in vitro assays. Altogether, our global approach combining high through put sequencing and functional studies will help us to define the physiopathological mechanisms and the molecular basis for clinical variability of NPH-associated ciliopathies and RHD and will contribute to develop new therapeutic approaches.
Profil The successful candidate will have a PhD in Cell Biology or Molecular Genetics, with strong experience in cell biology, signaling, development and/or zebrafish model. Salary will be commensurate to previous experience and in line with EU standards.
Location
Saunier’s group is part of the Imagine Institute (Institute of Genetic Diseases) at the Necker campus in Paris. The campus is well equipped with core facilities including biobank, centralized animal facilities (including zebrafish), cell imagining (confocal microscopy, live cell imaging), genomics core facility (high throughput sequencing technology on SOLiD5 System and Illumina platform) and the Paris Descartes University Bioinformatic Core Facility.
Imagine Institut new building
Candidature A cover letter and CV, as well as the names of at least two academic references should be e-mailed to Sophie Saunier (sophie.saunier@inserm.fr), Inserm U983, Imagine Institute, Hôpital Necker-Enfants Malades, Tour Lavoisier 6e, 149 rue de Sèvres, 75015 Paris, France.

Post-Doctoral positions in Ireland

Post-Doctoral Researcher in microRNAs and Neuroscience, Dublin, Ireland

**


   The Centre for the Study of Neurological Disorders at the Royal
   College of Surgeons in Ireland (Dublin, Ireland) is seeking an
   excellent Post-Doctoral Researcher to carry out studies on the role of
   microRNAs in epilepsy. The project will involve identification and
   functional studies on microRNAs and their targets within the brain in
   experimental models and human tissue. Applicants should have a
   background in neuroscience or equivalent discipline, and strong skills
   with human/mouse genetics, biochemistry, molecular biology, cell
   biology and bioinformatics.

Recent publications by the group: Jimenez-Mateos /et al./ (2012) /Nat
Med /18(7):1087-94;

*Appointment: *The post is available immediately for up to three
years.Salary is based on experience. Interested candidates are invited
to submit their CV along with a brief cover letter and names of two
referees to dhenshall@rcsi.ie <mailto:dhenshall@rcsi.ie>

Post-Doctoral Researcher in Neuroscience, Dublin, Ireland

**


   A Post-Doctoral position is available in the laboratory of Prof. David
   Henshall within the Centre for the Study of Neurological Disorders at
   the Royal College of Surgeons in Ireland (Dublin, Ireland). The
   project will explore the function of small non-coding RNAs including
   microRNAs in experimental models of epilepsy. Applicants should have a
   background in neuroscience or equivalent discipline, and expertise
   with in vivo electrophysiology, animal models, cognition/behaviour,
   drug delivery and histopathology.

Recent publications by the group: Jimenez-Mateos et al. /Nat Med
/18(7):1087-94 (2012); Engel et al. /Brain/ 136:577-92 (2013)

*Appointment: *The post is available immediately for up to three
years.Salary is based on experience. Interested candidates are invited
to submit their CV along with a brief cover letter and names of two
referees to dhenshall@rcsi.ie <mailto:dhenshall@rcsi.ie>

POSITION OPEN: RESEARCH FELLOW

Albert Einstein College of Medicine, Bronx, NY, United States
An NIH-­‐‑funded postdoctoral position is available at the Departments of Ophthalmology and Visual Sciences
and Genetics, Albert Einstein College of Medicine, to study chromatin remodeling, extracellular signaling,
microRNAs and mechanism of cell cycle exit control during embryonic development in mouse, zebrafish and
in differentiating embryonic stem (ES) cell studies. Our research is focused on genetic and epigenetic
regulatory mechanisms in mammalian eye development and disease.
Interested candidates must be highly motivated and hold a PhD or MD degree. A strong background and
expertise in molecular and cell biology is desired. Interested individuals should send their Curriculum Vitae,
and the contact information of three references to:
Dr. Ales Cvekl, Depts. of Ophthalmology and Visual Sciences and Genetics, Albert Einstein College of
Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461, E-­‐‑mail:
ales.cvekl@einstein.yu.edu. EEO

POST-DOCTORAL POSITION

The "Symbiosis and redox state" group at the Sophia Agrobiotech Institute (ISA, UMR 1355 INRA / University of Nice – Sophia Antipolis / 7254 CNRS) is seeking a highly motivated post-doctoral scientist for two years to join a National Research Agency (ANR) project entitled “ChAnnels and Reactive Oxygen species in Legume root hair: role in Symbiosis with Rhizobium” (CAROLS).

The ISA research unit is part of the SignaLife Labex and is located in the Sophia Antipolis technopole, with a well sound scientific environment (CNRS, INRA, University).

The postdoc will work in tight interaction with the two partners of the project situated in Montpellier (BPMP, Hervé Sentenac) and Gif sur Yvette (ISV, Jean-Marie Frachisse), allowing the best use of the know-how of each project participant.

The aim of the project is (i) to identify root hair plasma membrane channels from the Medicago truncatula model plant, (ii) to evaluate their regulation by reactive oxygen species and (iii) to perform a functional analysis of selected candidates during the symbiotic interaction with Sinorhizobium meliloti.

During the project, the post-doctoral scientist will study the regulation of root hair channels by NADPH oxidase-driven reactive oxygen species and its role in the symbiotic interaction.

He/she should have good expertise in molecular physiology (from gene cloning to functional analysis through mutant/transgenic plant characterization). A previous experience in imaging would be appreciated.

Application, including a detailed CV, a brief summary of research interests, names and addresses of two referees, should be addressed to Pr. Alain Puppo.

Contact: Pr. Alain Puppo, UMR INRA1355/CNRS7254/University of Nice-Sophia Antipolis Institut Sophia Agrobiotech, 400 route des Chappes, BP 167, 06903 Sophia Antipolis cedex, France. Tel: 33 (0) 492 386 631. email: puppo@unice.fr